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Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms
Background: Antenatal depression (AD) is a major public health issue worldwide and lacks objective laboratory-based tests to support its diagnosis. Recently, small metabolic molecules have been found to play a vital role in interpreting the pathogenesis of AD. Thus, non-target metabolomics was condu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295540/ https://www.ncbi.nlm.nih.gov/pubmed/34305679 http://dx.doi.org/10.3389/fpsyt.2021.679451 |
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author | Mao, Qiang Tian, Tian Chen, Jing Guo, Xunyi Zhang, Xueli Zou, Tao |
author_facet | Mao, Qiang Tian, Tian Chen, Jing Guo, Xunyi Zhang, Xueli Zou, Tao |
author_sort | Mao, Qiang |
collection | PubMed |
description | Background: Antenatal depression (AD) is a major public health issue worldwide and lacks objective laboratory-based tests to support its diagnosis. Recently, small metabolic molecules have been found to play a vital role in interpreting the pathogenesis of AD. Thus, non-target metabolomics was conducted in serum. Methods: Liquid chromatography—tandem mass spectrometry—based metabolomics platforms were used to conduct serum metabolic profiling of AD and non-antenatal depression (NAD). Orthogonal partial least squares discriminant analysis, the non-parametric Mann–Whitney U test, and Benjamini–Hochberg correction were used to identify the differential metabolites between AD and NAD groups; Spearman's correlation between the key differential metabolites and Edinburgh Postnatal Depression Scale (EPDS) and the stepwise logistic regression analysis was used to identify potential biomarkers. Results: In total, 79 significant differential metabolites between AD and NAD were identified. These metabolites mainly influence amino acid metabolism and glycerophospholipid metabolism. Then, PC (16:0/16:0) and betaine were significantly positively correlated with EPDS. The simplified biomarker panel consisting of these three metabolites [betaine, PC (16:0/16:0) and succinic acid] has excellent diagnostic performance (95% confidence interval = 0.911–1.000, specificity = 95%, sensitivity = 85%) in discriminating AD and NAD. Conclusion: The results suggested that betaine, PC (16:0/16:0), and succinic acid were potential biomarker panels, which significantly correlated with depression; and it could make for developing an objective method in future to diagnose AD. |
format | Online Article Text |
id | pubmed-8295540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82955402021-07-23 Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms Mao, Qiang Tian, Tian Chen, Jing Guo, Xunyi Zhang, Xueli Zou, Tao Front Psychiatry Psychiatry Background: Antenatal depression (AD) is a major public health issue worldwide and lacks objective laboratory-based tests to support its diagnosis. Recently, small metabolic molecules have been found to play a vital role in interpreting the pathogenesis of AD. Thus, non-target metabolomics was conducted in serum. Methods: Liquid chromatography—tandem mass spectrometry—based metabolomics platforms were used to conduct serum metabolic profiling of AD and non-antenatal depression (NAD). Orthogonal partial least squares discriminant analysis, the non-parametric Mann–Whitney U test, and Benjamini–Hochberg correction were used to identify the differential metabolites between AD and NAD groups; Spearman's correlation between the key differential metabolites and Edinburgh Postnatal Depression Scale (EPDS) and the stepwise logistic regression analysis was used to identify potential biomarkers. Results: In total, 79 significant differential metabolites between AD and NAD were identified. These metabolites mainly influence amino acid metabolism and glycerophospholipid metabolism. Then, PC (16:0/16:0) and betaine were significantly positively correlated with EPDS. The simplified biomarker panel consisting of these three metabolites [betaine, PC (16:0/16:0) and succinic acid] has excellent diagnostic performance (95% confidence interval = 0.911–1.000, specificity = 95%, sensitivity = 85%) in discriminating AD and NAD. Conclusion: The results suggested that betaine, PC (16:0/16:0), and succinic acid were potential biomarker panels, which significantly correlated with depression; and it could make for developing an objective method in future to diagnose AD. Frontiers Media S.A. 2021-07-08 /pmc/articles/PMC8295540/ /pubmed/34305679 http://dx.doi.org/10.3389/fpsyt.2021.679451 Text en Copyright © 2021 Mao, Tian, Chen, Guo, Zhang and Zou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Mao, Qiang Tian, Tian Chen, Jing Guo, Xunyi Zhang, Xueli Zou, Tao Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms |
title | Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms |
title_full | Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms |
title_fullStr | Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms |
title_full_unstemmed | Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms |
title_short | Serum Metabolic Profiling of Late-Pregnant Women With Antenatal Depressive Symptoms |
title_sort | serum metabolic profiling of late-pregnant women with antenatal depressive symptoms |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295540/ https://www.ncbi.nlm.nih.gov/pubmed/34305679 http://dx.doi.org/10.3389/fpsyt.2021.679451 |
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