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Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis

Purpose: To evaluate whether dry eye deteriorates after phacoemulsification cataract surgery, and to explore the influential factors. Methods: Studies published before February 2020 indexed on PubMed and the Cochrane Central Register of Controlled Trials were retrieved. A meta-analysis, including me...

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Autores principales: Lu, Qiang, Lu, Yi, Zhu, Xiangjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295542/
https://www.ncbi.nlm.nih.gov/pubmed/34307395
http://dx.doi.org/10.3389/fmed.2021.649030
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author Lu, Qiang
Lu, Yi
Zhu, Xiangjia
author_facet Lu, Qiang
Lu, Yi
Zhu, Xiangjia
author_sort Lu, Qiang
collection PubMed
description Purpose: To evaluate whether dry eye deteriorates after phacoemulsification cataract surgery, and to explore the influential factors. Methods: Studies published before February 2020 indexed on PubMed and the Cochrane Central Register of Controlled Trials were retrieved. A meta-analysis, including meta-regression, a sensitivity analysis, and a subgroup analysis, were performed. Results: Twenty studies with 2,247 eyes were included in the meta-analysis, dry eye-related parameters were investigated preoperatively and 1 month postoperatively. Patients with pre-existing meibomian gland dysfunction (MGD) had worsened subjective symptoms of dry eye (1.31, 95% confidence interval (CI) [0.66, 1.95], P < 0.0001), a reduced tear break-up time (BUT) (−2.27, 95% CI [−2.66, −1.88], P < 0.0001), and a worse corneal fluorescein staining (CFS) score (0.75, 95% CI [0.5, 1.0], P < 0.0001) after phacoemulsification cataract surgery, whereas in the general population, the subjective symptoms score and CFS remained unchanged and BUT decreased slightly after surgery. Patients without diabetes showed significantly reduced total tear secretion after phacoemulsification cataract surgery (−1.25, 95% CI [−1.62, −0.88], P < 0.0001). Conclusion: Dry eye generally remained unchanged 1 month after phacoemulsification cataract surgery. Notably, worsened symptoms and signs of dry eye were observed more frequently in patients with pre-existing MGD. Patients without diabetes were more susceptible to reduced tearing postoperatively. Clinical Trial Registration: Identifier: PERSPERO (2020: CRD42020203316).
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spelling pubmed-82955422021-07-23 Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis Lu, Qiang Lu, Yi Zhu, Xiangjia Front Med (Lausanne) Medicine Purpose: To evaluate whether dry eye deteriorates after phacoemulsification cataract surgery, and to explore the influential factors. Methods: Studies published before February 2020 indexed on PubMed and the Cochrane Central Register of Controlled Trials were retrieved. A meta-analysis, including meta-regression, a sensitivity analysis, and a subgroup analysis, were performed. Results: Twenty studies with 2,247 eyes were included in the meta-analysis, dry eye-related parameters were investigated preoperatively and 1 month postoperatively. Patients with pre-existing meibomian gland dysfunction (MGD) had worsened subjective symptoms of dry eye (1.31, 95% confidence interval (CI) [0.66, 1.95], P < 0.0001), a reduced tear break-up time (BUT) (−2.27, 95% CI [−2.66, −1.88], P < 0.0001), and a worse corneal fluorescein staining (CFS) score (0.75, 95% CI [0.5, 1.0], P < 0.0001) after phacoemulsification cataract surgery, whereas in the general population, the subjective symptoms score and CFS remained unchanged and BUT decreased slightly after surgery. Patients without diabetes showed significantly reduced total tear secretion after phacoemulsification cataract surgery (−1.25, 95% CI [−1.62, −0.88], P < 0.0001). Conclusion: Dry eye generally remained unchanged 1 month after phacoemulsification cataract surgery. Notably, worsened symptoms and signs of dry eye were observed more frequently in patients with pre-existing MGD. Patients without diabetes were more susceptible to reduced tearing postoperatively. Clinical Trial Registration: Identifier: PERSPERO (2020: CRD42020203316). Frontiers Media S.A. 2021-07-08 /pmc/articles/PMC8295542/ /pubmed/34307395 http://dx.doi.org/10.3389/fmed.2021.649030 Text en Copyright © 2021 Lu, Lu and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Lu, Qiang
Lu, Yi
Zhu, Xiangjia
Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis
title Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis
title_full Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis
title_fullStr Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis
title_full_unstemmed Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis
title_short Dry Eye and Phacoemulsification Cataract Surgery: A Systematic Review and Meta-Analysis
title_sort dry eye and phacoemulsification cataract surgery: a systematic review and meta-analysis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295542/
https://www.ncbi.nlm.nih.gov/pubmed/34307395
http://dx.doi.org/10.3389/fmed.2021.649030
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