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Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection

OBJECTIVE: Describe the diagnosis, clinical course, and management of a dog with systemic Mycoleptodiscus indicus infection. CASE SUMMARY: A 5‐year‐old male neutered Giant Schnauzer presented with left eye anterior uveitis, peripheral lymphadenopathy, hyperglobulinemia, anemia, and thrombocytopenia....

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Detalles Bibliográficos
Autores principales: Crespo‐Szabo, Sara M., Stafford, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295661/
https://www.ncbi.nlm.nih.gov/pubmed/34048620
http://dx.doi.org/10.1111/jvim.16182
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author Crespo‐Szabo, Sara M.
Stafford, Jennifer R.
author_facet Crespo‐Szabo, Sara M.
Stafford, Jennifer R.
author_sort Crespo‐Szabo, Sara M.
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description OBJECTIVE: Describe the diagnosis, clinical course, and management of a dog with systemic Mycoleptodiscus indicus infection. CASE SUMMARY: A 5‐year‐old male neutered Giant Schnauzer presented with left eye anterior uveitis, peripheral lymphadenopathy, hyperglobulinemia, anemia, and thrombocytopenia. A diagnosis of M. indicus infection was made based on histopathology and PCR. Treatment with itraconazole and terbinafine resulted in resolution of the hyperglobulinemia, anemia, thrombocytopenia, and peripheral lymphadenopathy. No evidence of fungal organisms was identified on lymph node, liver, or ocular histopathology after 7 months of treatment. NEW OR UNIQUE INFORMATION PROVIDED: This case is the first report of a systemic M. indicus infection in an apparently immunocompetent dog. Clinical resolution was achieved with systemic itraconazole and terbinafine.
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spelling pubmed-82956612021-07-27 Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection Crespo‐Szabo, Sara M. Stafford, Jennifer R. J Vet Intern Med SMALL ANIMAL OBJECTIVE: Describe the diagnosis, clinical course, and management of a dog with systemic Mycoleptodiscus indicus infection. CASE SUMMARY: A 5‐year‐old male neutered Giant Schnauzer presented with left eye anterior uveitis, peripheral lymphadenopathy, hyperglobulinemia, anemia, and thrombocytopenia. A diagnosis of M. indicus infection was made based on histopathology and PCR. Treatment with itraconazole and terbinafine resulted in resolution of the hyperglobulinemia, anemia, thrombocytopenia, and peripheral lymphadenopathy. No evidence of fungal organisms was identified on lymph node, liver, or ocular histopathology after 7 months of treatment. NEW OR UNIQUE INFORMATION PROVIDED: This case is the first report of a systemic M. indicus infection in an apparently immunocompetent dog. Clinical resolution was achieved with systemic itraconazole and terbinafine. John Wiley & Sons, Inc. 2021-05-28 2021 /pmc/articles/PMC8295661/ /pubmed/34048620 http://dx.doi.org/10.1111/jvim.16182 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Crespo‐Szabo, Sara M.
Stafford, Jennifer R.
Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection
title Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection
title_full Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection
title_fullStr Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection
title_full_unstemmed Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection
title_short Diagnosis, treatment, and outcome in a dog with systemic Mycoleptodiscus indicus infection
title_sort diagnosis, treatment, and outcome in a dog with systemic mycoleptodiscus indicus infection
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295661/
https://www.ncbi.nlm.nih.gov/pubmed/34048620
http://dx.doi.org/10.1111/jvim.16182
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