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Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls

BACKGROUND: In dogs, antiepileptic drugs (AED) cause lethargy but quantitative data regarding the effects of AED on activity levels are not available, and little is known about how AEDs affect sleep quality. OBJECTIVE: To quantitatively compare activity levels and nocturnal activity in dogs previous...

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Autores principales: Barry, Megan, Cameron, Starr, Kent, Sean, Barnes‐Heller, Heidi, Grady, Kylie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295678/
https://www.ncbi.nlm.nih.gov/pubmed/34223667
http://dx.doi.org/10.1111/jvim.16205
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author Barry, Megan
Cameron, Starr
Kent, Sean
Barnes‐Heller, Heidi
Grady, Kylie
author_facet Barry, Megan
Cameron, Starr
Kent, Sean
Barnes‐Heller, Heidi
Grady, Kylie
author_sort Barry, Megan
collection PubMed
description BACKGROUND: In dogs, antiepileptic drugs (AED) cause lethargy but quantitative data regarding the effects of AED on activity levels are not available, and little is known about how AEDs affect sleep quality. OBJECTIVE: To quantitatively compare activity levels and nocturnal activity in dogs previously diagnosed with idiopathic epilepsy (IE) receiving AEDs compared to age‐ and breed‐matched control dogs. ANIMALS: Sixty‐two dogs with IE and 310 control dogs. METHODS: This is a 3‐month prospective parallel observational study. An activity monitoring device for dogs was used to measure daily activity levels and sleep scores in all dogs. RESULTS: Dogs with IE treated with AEDs had an 18% average lower baseline activity level compared to control dogs (P = .005; point estimate = 0.82, 95% confidence interval [CI], 0.75‐0.90). The combination of phenobarbital and potassium bromide (KBr) was associated with an average 28% decrease in activity in dogs with IE compared to control dogs (P = .03; point estimate = 0.72; CI, 0.62‐0.82). Mean sleep scores were not significantly different in dogs with IE receiving AEDs compared to control dogs (P = .43). However, higher dosages of KBr were associated with lower sleep scores (P = .01). CONCLUSIONS: Dogs with IE receiving AEDs have lower activity levels, but no difference in sleep scores, compared to controls. The combination of phenobarbital and KBr had the largest decrease in activity between groups. Higher doses of KBr may affect nocturnal activity in epileptic dogs.
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spelling pubmed-82956782021-07-27 Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls Barry, Megan Cameron, Starr Kent, Sean Barnes‐Heller, Heidi Grady, Kylie J Vet Intern Med SMALL ANIMAL BACKGROUND: In dogs, antiepileptic drugs (AED) cause lethargy but quantitative data regarding the effects of AED on activity levels are not available, and little is known about how AEDs affect sleep quality. OBJECTIVE: To quantitatively compare activity levels and nocturnal activity in dogs previously diagnosed with idiopathic epilepsy (IE) receiving AEDs compared to age‐ and breed‐matched control dogs. ANIMALS: Sixty‐two dogs with IE and 310 control dogs. METHODS: This is a 3‐month prospective parallel observational study. An activity monitoring device for dogs was used to measure daily activity levels and sleep scores in all dogs. RESULTS: Dogs with IE treated with AEDs had an 18% average lower baseline activity level compared to control dogs (P = .005; point estimate = 0.82, 95% confidence interval [CI], 0.75‐0.90). The combination of phenobarbital and potassium bromide (KBr) was associated with an average 28% decrease in activity in dogs with IE compared to control dogs (P = .03; point estimate = 0.72; CI, 0.62‐0.82). Mean sleep scores were not significantly different in dogs with IE receiving AEDs compared to control dogs (P = .43). However, higher dosages of KBr were associated with lower sleep scores (P = .01). CONCLUSIONS: Dogs with IE receiving AEDs have lower activity levels, but no difference in sleep scores, compared to controls. The combination of phenobarbital and KBr had the largest decrease in activity between groups. Higher doses of KBr may affect nocturnal activity in epileptic dogs. John Wiley & Sons, Inc. 2021-07-05 2021 /pmc/articles/PMC8295678/ /pubmed/34223667 http://dx.doi.org/10.1111/jvim.16205 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Barry, Megan
Cameron, Starr
Kent, Sean
Barnes‐Heller, Heidi
Grady, Kylie
Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls
title Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls
title_full Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls
title_fullStr Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls
title_full_unstemmed Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls
title_short Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls
title_sort daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295678/
https://www.ncbi.nlm.nih.gov/pubmed/34223667
http://dx.doi.org/10.1111/jvim.16205
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