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Clinical features, diagnosis, and survival analysis of dogs with glioma
BACKGROUND: Gliomas in dogs remain poorly understood. OBJECTIVES: To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification. ANIMALS: Ninety‐one dogs with histo...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295679/ https://www.ncbi.nlm.nih.gov/pubmed/34117807 http://dx.doi.org/10.1111/jvim.16199 |
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author | José‐López, Roberto Gutierrez‐Quintana, Rodrigo de la Fuente, Cristian Manzanilla, Edgar G. Suñol, Anna Pi Castro, Dolors Añor, Sonia Sánchez‐Masian, Daniel Fernández‐Flores, Francisco Ricci, Emanuele Marioni‐Henry, Katia Mascort, Joan Matiasek, Lara A. Matiasek, Kaspar Brennan, Paul M. Pumarola, Martí |
author_facet | José‐López, Roberto Gutierrez‐Quintana, Rodrigo de la Fuente, Cristian Manzanilla, Edgar G. Suñol, Anna Pi Castro, Dolors Añor, Sonia Sánchez‐Masian, Daniel Fernández‐Flores, Francisco Ricci, Emanuele Marioni‐Henry, Katia Mascort, Joan Matiasek, Lara A. Matiasek, Kaspar Brennan, Paul M. Pumarola, Martí |
author_sort | José‐López, Roberto |
collection | PubMed |
description | BACKGROUND: Gliomas in dogs remain poorly understood. OBJECTIVES: To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification. ANIMALS: Ninety‐one dogs with histopathological diagnosis of glioma. METHODS: Multicentric retrospective case series. Signalment, clinicopathologic findings, diagnostic imaging characteristics, treatment, and outcome were used. Tumors were reclassified according to the new canine glioma diagnostic scheme. RESULTS: No associations were found between clinicopathologic findings or survival and tumor type or grade. However, definitive treatments provided significantly (P = .03) improved median survival time (84 days; 95% confidence interval [CI], 45‐190) compared to palliative treatment (26 days; 95% CI, 11‐54). On magnetic resonance imaging (MRI), oligodendrogliomas were associated with smooth margins and T1‐weighted hypointensity compared to astrocytomas (odds ratio [OR], 42.5; 95% CI, 2.42‐744.97; P = .04; OR, 45.5; 95% CI, 5.78‐333.33; P < .001, respectively) and undefined gliomas (OR, 84; 95% CI, 3.43‐999.99; P = .02; OR, 32.3; 95% CI, 2.51‐500.00; P = .008, respectively) and were more commonly in contact with the ventricles than astrocytomas (OR, 7.47; 95% CI, 1.03‐53.95; P = .049). Tumor spread to neighboring brain structures was associated with high‐grade glioma (OR, 6.02; 95% CI, 1.06‐34.48; P = .04). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with gliomas have poor outcomes, but risk factors identified in survival analysis inform prognosis and the newly identified MRI characteristics could refine diagnosis of tumor type and grade. |
format | Online Article Text |
id | pubmed-8295679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82956792021-07-27 Clinical features, diagnosis, and survival analysis of dogs with glioma José‐López, Roberto Gutierrez‐Quintana, Rodrigo de la Fuente, Cristian Manzanilla, Edgar G. Suñol, Anna Pi Castro, Dolors Añor, Sonia Sánchez‐Masian, Daniel Fernández‐Flores, Francisco Ricci, Emanuele Marioni‐Henry, Katia Mascort, Joan Matiasek, Lara A. Matiasek, Kaspar Brennan, Paul M. Pumarola, Martí J Vet Intern Med SMALL ANIMAL BACKGROUND: Gliomas in dogs remain poorly understood. OBJECTIVES: To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification. ANIMALS: Ninety‐one dogs with histopathological diagnosis of glioma. METHODS: Multicentric retrospective case series. Signalment, clinicopathologic findings, diagnostic imaging characteristics, treatment, and outcome were used. Tumors were reclassified according to the new canine glioma diagnostic scheme. RESULTS: No associations were found between clinicopathologic findings or survival and tumor type or grade. However, definitive treatments provided significantly (P = .03) improved median survival time (84 days; 95% confidence interval [CI], 45‐190) compared to palliative treatment (26 days; 95% CI, 11‐54). On magnetic resonance imaging (MRI), oligodendrogliomas were associated with smooth margins and T1‐weighted hypointensity compared to astrocytomas (odds ratio [OR], 42.5; 95% CI, 2.42‐744.97; P = .04; OR, 45.5; 95% CI, 5.78‐333.33; P < .001, respectively) and undefined gliomas (OR, 84; 95% CI, 3.43‐999.99; P = .02; OR, 32.3; 95% CI, 2.51‐500.00; P = .008, respectively) and were more commonly in contact with the ventricles than astrocytomas (OR, 7.47; 95% CI, 1.03‐53.95; P = .049). Tumor spread to neighboring brain structures was associated with high‐grade glioma (OR, 6.02; 95% CI, 1.06‐34.48; P = .04). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with gliomas have poor outcomes, but risk factors identified in survival analysis inform prognosis and the newly identified MRI characteristics could refine diagnosis of tumor type and grade. John Wiley & Sons, Inc. 2021-06-12 2021 /pmc/articles/PMC8295679/ /pubmed/34117807 http://dx.doi.org/10.1111/jvim.16199 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL José‐López, Roberto Gutierrez‐Quintana, Rodrigo de la Fuente, Cristian Manzanilla, Edgar G. Suñol, Anna Pi Castro, Dolors Añor, Sonia Sánchez‐Masian, Daniel Fernández‐Flores, Francisco Ricci, Emanuele Marioni‐Henry, Katia Mascort, Joan Matiasek, Lara A. Matiasek, Kaspar Brennan, Paul M. Pumarola, Martí Clinical features, diagnosis, and survival analysis of dogs with glioma |
title | Clinical features, diagnosis, and survival analysis of dogs with glioma |
title_full | Clinical features, diagnosis, and survival analysis of dogs with glioma |
title_fullStr | Clinical features, diagnosis, and survival analysis of dogs with glioma |
title_full_unstemmed | Clinical features, diagnosis, and survival analysis of dogs with glioma |
title_short | Clinical features, diagnosis, and survival analysis of dogs with glioma |
title_sort | clinical features, diagnosis, and survival analysis of dogs with glioma |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295679/ https://www.ncbi.nlm.nih.gov/pubmed/34117807 http://dx.doi.org/10.1111/jvim.16199 |
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