Cargando…

Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing

The NUP214-ABL1 fusion gene is a constitutively active tyrosine kinase that can be detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients, and it can also be found in B-cell acute lymphoblastic leukaemia (B-ALL). However the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Huan-Ping, He, Jun-Jun, Zhu, Qiao-Yun, Wang, Lin, Li, Jian-Hu, Huang, Jian-Song, Xie, Wan-Zhuo, Zhu, Hong-Hu, Jin, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295748/
https://www.ncbi.nlm.nih.gov/pubmed/34307175
http://dx.doi.org/10.3389/fonc.2021.706798
_version_ 1783725498445070336
author Wang, Huan-Ping
He, Jun-Jun
Zhu, Qiao-Yun
Wang, Lin
Li, Jian-Hu
Huang, Jian-Song
Xie, Wan-Zhuo
Zhu, Hong-Hu
Jin, Jie
author_facet Wang, Huan-Ping
He, Jun-Jun
Zhu, Qiao-Yun
Wang, Lin
Li, Jian-Hu
Huang, Jian-Song
Xie, Wan-Zhuo
Zhu, Hong-Hu
Jin, Jie
author_sort Wang, Huan-Ping
collection PubMed
description The NUP214-ABL1 fusion gene is a constitutively active tyrosine kinase that can be detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients, and it can also be found in B-cell acute lymphoblastic leukaemia (B-ALL). However the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not yet been reported. Up to now, the sensitivity of NUP214-ABL1-positive patients to tyrosine kinase inhibitor (TKI) is still controversial. Here we report the first case of an AML patient carrying NUP214-ABL1 fusion gene. The conventional AML chemotherapy regimen for the patient was successful. Identification of additional AML patients with NUP214-ABL1 fusion gene will provide treatment experience and prognostic evaluation.
format Online
Article
Text
id pubmed-8295748
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82957482021-07-23 Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing Wang, Huan-Ping He, Jun-Jun Zhu, Qiao-Yun Wang, Lin Li, Jian-Hu Huang, Jian-Song Xie, Wan-Zhuo Zhu, Hong-Hu Jin, Jie Front Oncol Oncology The NUP214-ABL1 fusion gene is a constitutively active tyrosine kinase that can be detected in 6% of T-cell acute lymphoblastic leukemia (T-ALL) patients, and it can also be found in B-cell acute lymphoblastic leukaemia (B-ALL). However the NUP214-ABL1 fusion in acute myeloid leukemia (AML) has not yet been reported. Up to now, the sensitivity of NUP214-ABL1-positive patients to tyrosine kinase inhibitor (TKI) is still controversial. Here we report the first case of an AML patient carrying NUP214-ABL1 fusion gene. The conventional AML chemotherapy regimen for the patient was successful. Identification of additional AML patients with NUP214-ABL1 fusion gene will provide treatment experience and prognostic evaluation. Frontiers Media S.A. 2021-07-08 /pmc/articles/PMC8295748/ /pubmed/34307175 http://dx.doi.org/10.3389/fonc.2021.706798 Text en Copyright © 2021 Wang, He, Zhu, Wang, Li, Huang, Xie, Zhu and Jin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Huan-Ping
He, Jun-Jun
Zhu, Qiao-Yun
Wang, Lin
Li, Jian-Hu
Huang, Jian-Song
Xie, Wan-Zhuo
Zhu, Hong-Hu
Jin, Jie
Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_full Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_fullStr Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_full_unstemmed Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_short Case Report: The First Report of NUP214-ABL1 Fusion Gene in Acute Myeloid Leukemia Patient Detected by Next-Generation Sequencing
title_sort case report: the first report of nup214-abl1 fusion gene in acute myeloid leukemia patient detected by next-generation sequencing
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295748/
https://www.ncbi.nlm.nih.gov/pubmed/34307175
http://dx.doi.org/10.3389/fonc.2021.706798
work_keys_str_mv AT wanghuanping casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT hejunjun casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT zhuqiaoyun casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT wanglin casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT lijianhu casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT huangjiansong casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT xiewanzhuo casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT zhuhonghu casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing
AT jinjie casereportthefirstreportofnup214abl1fusiongeneinacutemyeloidleukemiapatientdetectedbynextgenerationsequencing