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Out-of-field dose in stereotactic radiotherapy for paediatric patients

BACKGROUND AND PURPOSE: Stereotactic radiotherapy combines image guidance and high precision delivery with small fields to deliver high doses per fraction in short treatment courses. In preparation for extension of these treatment techniques to paediatric patients we characterised and compared doses...

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Autores principales: Garrett, Lachlan, Hardcastle, Nicholas, Yeo, Adam, Lonski, Peta, Franich, Rick, Kron, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295843/
https://www.ncbi.nlm.nih.gov/pubmed/34307913
http://dx.doi.org/10.1016/j.phro.2021.05.006
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author Garrett, Lachlan
Hardcastle, Nicholas
Yeo, Adam
Lonski, Peta
Franich, Rick
Kron, Tomas
author_facet Garrett, Lachlan
Hardcastle, Nicholas
Yeo, Adam
Lonski, Peta
Franich, Rick
Kron, Tomas
author_sort Garrett, Lachlan
collection PubMed
description BACKGROUND AND PURPOSE: Stereotactic radiotherapy combines image guidance and high precision delivery with small fields to deliver high doses per fraction in short treatment courses. In preparation for extension of these treatment techniques to paediatric patients we characterised and compared doses out-of-field in a paediatric anthropomorphic phantom for small flattened and flattening filter free (FFF) photon beams. METHOD AND MATERIALS: Dose measurements were taken in several organs and structures outside the primary field in an anthropomorphic phantom of a 5 year old child (CIRS) using thermoluminescence dosimetry (LiF:Mg,Cu,P). Out-of-field doses from a medical linear accelerator were assessed for 6 MV flattened and FFF beams of field sizes between 2 × 2 and 10 × 10 cm(2). RESULTS: FFF beams resulted in reduced out-of-field doses for all field sizes when compared to flattened beams. Doses for FFF and flattened beams converged for all field sizes at larger distances (>40 cm) from the central axis as leakage becomes the primary source of out-of-field dose. Rotating the collimator to place the MLC bank in the longitudinal axis of the patient was shown to reduce the peripheral doses measured by up to 50% in Varian linear accelerators. CONCLUSION: Minimising out-of-field doses by using FFF beams and aligning the couch and collimator to provide tertiary shielding demonstrated advantages of small field, FFF treatments in a paediatric setting.
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spelling pubmed-82958432021-07-23 Out-of-field dose in stereotactic radiotherapy for paediatric patients Garrett, Lachlan Hardcastle, Nicholas Yeo, Adam Lonski, Peta Franich, Rick Kron, Tomas Phys Imaging Radiat Oncol Original Research Article BACKGROUND AND PURPOSE: Stereotactic radiotherapy combines image guidance and high precision delivery with small fields to deliver high doses per fraction in short treatment courses. In preparation for extension of these treatment techniques to paediatric patients we characterised and compared doses out-of-field in a paediatric anthropomorphic phantom for small flattened and flattening filter free (FFF) photon beams. METHOD AND MATERIALS: Dose measurements were taken in several organs and structures outside the primary field in an anthropomorphic phantom of a 5 year old child (CIRS) using thermoluminescence dosimetry (LiF:Mg,Cu,P). Out-of-field doses from a medical linear accelerator were assessed for 6 MV flattened and FFF beams of field sizes between 2 × 2 and 10 × 10 cm(2). RESULTS: FFF beams resulted in reduced out-of-field doses for all field sizes when compared to flattened beams. Doses for FFF and flattened beams converged for all field sizes at larger distances (>40 cm) from the central axis as leakage becomes the primary source of out-of-field dose. Rotating the collimator to place the MLC bank in the longitudinal axis of the patient was shown to reduce the peripheral doses measured by up to 50% in Varian linear accelerators. CONCLUSION: Minimising out-of-field doses by using FFF beams and aligning the couch and collimator to provide tertiary shielding demonstrated advantages of small field, FFF treatments in a paediatric setting. Elsevier 2021-06-04 /pmc/articles/PMC8295843/ /pubmed/34307913 http://dx.doi.org/10.1016/j.phro.2021.05.006 Text en © 2021 The Authors. Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Garrett, Lachlan
Hardcastle, Nicholas
Yeo, Adam
Lonski, Peta
Franich, Rick
Kron, Tomas
Out-of-field dose in stereotactic radiotherapy for paediatric patients
title Out-of-field dose in stereotactic radiotherapy for paediatric patients
title_full Out-of-field dose in stereotactic radiotherapy for paediatric patients
title_fullStr Out-of-field dose in stereotactic radiotherapy for paediatric patients
title_full_unstemmed Out-of-field dose in stereotactic radiotherapy for paediatric patients
title_short Out-of-field dose in stereotactic radiotherapy for paediatric patients
title_sort out-of-field dose in stereotactic radiotherapy for paediatric patients
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295843/
https://www.ncbi.nlm.nih.gov/pubmed/34307913
http://dx.doi.org/10.1016/j.phro.2021.05.006
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