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A Single Point Mutation Controls the Rate of Interconversion Between the g (+) and g (−) Rotamers of the Histidine 189 χ2 Angle That Activates Bacterial Enzyme I for Catalysis
Enzyme I (EI) of the bacterial phosphotransferase system (PTS) is a master regulator of bacterial metabolism and a promising target for development of a new class of broad-spectrum antibiotics. The catalytic activity of EI is mediated by several intradomain, interdomain, and intersubunit conformatio...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295985/ https://www.ncbi.nlm.nih.gov/pubmed/34307459 http://dx.doi.org/10.3389/fmolb.2021.699203 |