Cargando…

A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment

Mastalgia, or breast pain, is common among women which can lead to significant impairment in daily living. Hence, finding an effective treatment that can alleviate the symptom is very important. Thus, we carry out this study to determine the efficacy of evening primrose oil (EPO) for mastalgia treat...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmad Adni, Lina Liana, Norhayati, Mohd Noor, Mohd Rosli, Ritzzaleena Rosli, Muhammad, Juliawati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296106/
https://www.ncbi.nlm.nih.gov/pubmed/34200727
http://dx.doi.org/10.3390/ijerph18126295
_version_ 1783725561512722432
author Ahmad Adni, Lina Liana
Norhayati, Mohd Noor
Mohd Rosli, Ritzzaleena Rosli
Muhammad, Juliawati
author_facet Ahmad Adni, Lina Liana
Norhayati, Mohd Noor
Mohd Rosli, Ritzzaleena Rosli
Muhammad, Juliawati
author_sort Ahmad Adni, Lina Liana
collection PubMed
description Mastalgia, or breast pain, is common among women which can lead to significant impairment in daily living. Hence, finding an effective treatment that can alleviate the symptom is very important. Thus, we carry out this study to determine the efficacy of evening primrose oil (EPO) for mastalgia treatment in women. The review included published randomised clinical trials that evaluated EPO used for treating mastalgia against a placebo or other treatments, irrespective of the blinding procedure, publication status, or sample size. Two independent authors screened the titles and abstracts of the identified trials; full texts of relevant trials were evaluated for eligibility. Two reviewers independently extracted data on the methods, interventions, outcomes, and risk of bias. The random-effects model was used for estimating the risk ratios and mean differences with 95% confidence intervals. Thirteen trials with 1752 randomised patients were included. The results showed that EPO has no difference to reduce breast pain compared to topical NSAIDS, danazol, or vitamin E. The number of patients who achieved pain relief was no different compared to the placebo or other treatments. The EPO does not increase adverse events, such as nausea, abdominal bloating, headache or giddiness, increase weight gain, and altered taste compared to a placebo or other treatments. EPO is a safe medication with similar efficacy for pain control in women with mastalgia compared to a placebo, topical NSAIDS, danazol, or vitamin E.
format Online
Article
Text
id pubmed-8296106
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82961062021-07-23 A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment Ahmad Adni, Lina Liana Norhayati, Mohd Noor Mohd Rosli, Ritzzaleena Rosli Muhammad, Juliawati Int J Environ Res Public Health Systematic Review Mastalgia, or breast pain, is common among women which can lead to significant impairment in daily living. Hence, finding an effective treatment that can alleviate the symptom is very important. Thus, we carry out this study to determine the efficacy of evening primrose oil (EPO) for mastalgia treatment in women. The review included published randomised clinical trials that evaluated EPO used for treating mastalgia against a placebo or other treatments, irrespective of the blinding procedure, publication status, or sample size. Two independent authors screened the titles and abstracts of the identified trials; full texts of relevant trials were evaluated for eligibility. Two reviewers independently extracted data on the methods, interventions, outcomes, and risk of bias. The random-effects model was used for estimating the risk ratios and mean differences with 95% confidence intervals. Thirteen trials with 1752 randomised patients were included. The results showed that EPO has no difference to reduce breast pain compared to topical NSAIDS, danazol, or vitamin E. The number of patients who achieved pain relief was no different compared to the placebo or other treatments. The EPO does not increase adverse events, such as nausea, abdominal bloating, headache or giddiness, increase weight gain, and altered taste compared to a placebo or other treatments. EPO is a safe medication with similar efficacy for pain control in women with mastalgia compared to a placebo, topical NSAIDS, danazol, or vitamin E. MDPI 2021-06-10 /pmc/articles/PMC8296106/ /pubmed/34200727 http://dx.doi.org/10.3390/ijerph18126295 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Ahmad Adni, Lina Liana
Norhayati, Mohd Noor
Mohd Rosli, Ritzzaleena Rosli
Muhammad, Juliawati
A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment
title A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment
title_full A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment
title_fullStr A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment
title_full_unstemmed A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment
title_short A Systematic Review and Meta-Analysis of the Efficacy of Evening Primrose Oil for Mastalgia Treatment
title_sort systematic review and meta-analysis of the efficacy of evening primrose oil for mastalgia treatment
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296106/
https://www.ncbi.nlm.nih.gov/pubmed/34200727
http://dx.doi.org/10.3390/ijerph18126295
work_keys_str_mv AT ahmadadnilinaliana asystematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment
AT norhayatimohdnoor asystematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment
AT mohdrosliritzzaleenarosli asystematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment
AT muhammadjuliawati asystematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment
AT ahmadadnilinaliana systematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment
AT norhayatimohdnoor systematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment
AT mohdrosliritzzaleenarosli systematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment
AT muhammadjuliawati systematicreviewandmetaanalysisoftheefficacyofeveningprimroseoilformastalgiatreatment