Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol

BACKGROUND: Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. CASE PRESENTATION: A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line tre...

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Autores principales: Lee, Erika Yue, Song, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296542/
https://www.ncbi.nlm.nih.gov/pubmed/34294117
http://dx.doi.org/10.1186/s13223-021-00578-7
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author Lee, Erika Yue
Song, Christine
author_facet Lee, Erika Yue
Song, Christine
author_sort Lee, Erika Yue
collection PubMed
description BACKGROUND: Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. CASE PRESENTATION: A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. As such, she completed a novel 12-step desensitization protocol to oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided after a month of being on daily ursodiol. CONCLUSION: Immediate hypersensitivity reaction to ursodiol is uncommon. Our case demonstrated that this novel desensitization protocol to ursodiol could be safely implemented when alternative options are not available or have proven inferior in efficacy.
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spelling pubmed-82965422021-07-22 Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol Lee, Erika Yue Song, Christine Allergy Asthma Clin Immunol Case Report BACKGROUND: Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. CASE PRESENTATION: A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. As such, she completed a novel 12-step desensitization protocol to oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided after a month of being on daily ursodiol. CONCLUSION: Immediate hypersensitivity reaction to ursodiol is uncommon. Our case demonstrated that this novel desensitization protocol to ursodiol could be safely implemented when alternative options are not available or have proven inferior in efficacy. BioMed Central 2021-07-22 /pmc/articles/PMC8296542/ /pubmed/34294117 http://dx.doi.org/10.1186/s13223-021-00578-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Lee, Erika Yue
Song, Christine
Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
title Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
title_full Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
title_fullStr Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
title_full_unstemmed Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
title_short Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
title_sort immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296542/
https://www.ncbi.nlm.nih.gov/pubmed/34294117
http://dx.doi.org/10.1186/s13223-021-00578-7
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