Cargando…

High-Throughput Virtual Screening for a New Class of Antagonist Targeting LasR of Pseudomonas aeruginosa

[Image: see text] Pseudomonas aeruginosa, an opportunistic human pathogen, causes fatal effects in patients with cystic fibrosis and immunocompromised individuals and leads to around 1000 deaths annually. The quorum sensing mechanism of P. aeruginosa plays a major role in promoting biofilm formation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vetrivel, Aishwarya, Natchimuthu, Santhi, Subramanian, Vidyalakshmi, Murugesan, Rajeswari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296597/ https://www.ncbi.nlm.nih.gov/pubmed/34308062 http://dx.doi.org/10.1021/acsomega.1c02191

Ejemplares similares

Pharmacophore and Virtual Screening of JAK3 inhibitors
por: Rajeswari, Murugesan, et al.
Publicado: (2014)

Virtual Screening of FDA-Approved Drugs against LasR of Pseudomonas aeruginosa for Antibiofilm Potential
por: Sadiq, Suhaib, et al.
Publicado: (2020)

Characterization of lasR-deficient clinical isolates of Pseudomonas aeruginosa
por: Wang, Yao, et al.
Publicado: (2018)

Isolation of the Autoinducer-Quenching Strain that Inhibits LasR in Pseudomonas aeruginosa
por: Weng, Lixing, et al.
Publicado: (2014)

Reversible Signal Binding by the Pseudomonas aeruginosa Quorum-Sensing Signal Receptor LasR
por: Sappington, Kaia J., et al.
Publicado: (2011)

Study on pyoverdine and biofilm production with detection of LasR gene in MDR Pseudomonas aeruginosa
por: Hamza, Esraa H., et al.
Publicado: (2023)

A New Transcriptional Repressor of the Pseudomonas aeruginosa Quorum Sensing Receptor Gene lasR
por: Longo, Francesca, et al.
Publicado: (2013)

Stationary Phase-Specific Virulence Factor Overproduction by a lasR Mutant of Pseudomonas aeruginosa
por: Cabeen, Matthew T.
Publicado: (2014)

Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung
por: Zhao, Kelei, et al.
Publicado: (2023)

Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains
por: Cugini, Carla, et al.
Publicado: (2010)

Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses
por: LaFayette, Shantelle L., et al.
Publicado: (2015)

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa
por: Feltner, John B., et al.
Publicado: (2016)

Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence in Pseudomonas aeruginosa PAO1
por: Xuan, Guanhua, et al.
Publicado: (2021)

Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates
por: Jeske, Alexander, et al.
Publicado: (2022)

Rise in frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021
por: Shanks, Robert M. Q., et al.
Publicado: (2023)

Environmentally Endemic Pseudomonas aeruginosa Strains with Mutations in lasR Are Associated with Increased Disease Severity in Corneal Ulcers
por: Hammond, John H., et al.
Publicado: (2016)

A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021
por: Shanks, Robert M. Q., et al.
Publicado: (2023)

The phage-encoded protein PIT2 impacts Pseudomonas aeruginosa quorum sensing by direct interaction with LasR
por: Schroven, Kaat, et al.
Publicado: (2023)

Microevolution of the mexT and lasR Reinforces the Bias of Quorum Sensing System in Laboratory Strains of Pseudomonas aeruginosa PAO1
por: Liu, Yang, et al.
Publicado: (2022)

Biofilm production by clinical isolates of Pseudomonas aeruginosa and structural changes in LasR protein of isolates non biofilm-producing
por: Lima, Jailton Lobo da Costa, et al.
Publicado: (2018)

In Silico Identification of Natural Food Compounds as Potential Quorum-Sensing Inhibitors Targeting the LasR Receptor of Pseudomonas aeruginosa
por: Magri, Meryam, et al.
Publicado: (2023)

Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa
por: Srinivasarao, Singireddi, et al.
Publicado: (2019)

LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation
por: Hennemann, Lisa C., et al.
Publicado: (2021)

Sennoside A inhibits quorum sensing system to attenuate its regulated virulence and pathogenicity via targeting LasR in Pseudomonas aeruginosa
por: Han, Xiaofeng, et al.
Publicado: (2022)

Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis
por: Santhi, Natchimuthu, et al.
Publicado: (2011)

Study of quorum-sensing LasR and RhlR genes and their dependent virulence factors in Pseudomonas aeruginosa isolates from infected burn wounds
por: Elnegery, Aya Ahmad, et al.
Publicado: (2021)

Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR)
por: Gajera, Gemini, et al.
Publicado: (2023)

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness
por: Mould, Dallas L., et al.
Publicado: (2023)

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness
por: Mould, Dallas L., et al.
Publicado: (2023)

Multidrug-resistant Pseudomonas aeruginosa is predisposed to lasR mutation through up-regulated activity of efflux pumps in non-cystic fibrosis bronchiectasis patients
por: Ding, Fengming, et al.
Publicado: (2022)

T2SS-peptidase XcpA associated with LasR evolutional phenotypic variations provides a fitness advantage to Pseudomonas aeruginosa PAO1
por: Cheng, Mengmeng, et al.
Publicado: (2023)

Surface growth of Pseudomonas aeruginosa reveals a regulatory effect of 3-oxo-C(12)-homoserine lactone in the absence of its cognate receptor, LasR
por: de Oliveira Pereira, Thays, et al.
Publicado: (2023)

Norlobaridone Inhibits Quorum Sensing-Dependent Biofilm Formation and Some Virulence Factors in Pseudomonas aeruginosa by Disrupting Its Transcriptional Activator Protein LasR Dimerization
por: Soltane, Raya, et al.
Publicado: (2023)

Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding
por: Hernando-Amado, Sara, et al.
Publicado: (2020)

Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR
por: Claussen, Anetta, et al.
Publicado: (2013)

A data-driven machine learning approach for discovering potent LasR inhibitors
por: Koh, Christabel Ming Ming, et al.
Publicado: (2023)

Quorum quenching activity of Andrographis paniculata (Burm f.) Nees andrographolide compounds on metallo-β-lactamase-producing clinical isolates of Pseudomonas aeruginosa PA22 and PA247 and their effect on lasR gene expression
por: Tan Lim, An Margarete, et al.
Publicado: (2021)

High-Throughput Identification of Antibacterials Against Pseudomonas aeruginosa
por: Li, Shijia, et al.
Publicado: (2020)

High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents
por: Kang, Donghoon, et al.
Publicado: (2021)

LasR-regulated proteases in acute vs. chronic lung infection: a double-edged sword
por: Hennemann, Lisa C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fpaso1nsnq4m4lhoarmhse9lo6