Metabolic landscapes in sarcomas

Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin, histological definition and underlying genetic history. Novel large-scale genomic and metabolomics approaches are...

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Autores principales: Miallot, Richard, Galland, Franck, Millet, Virginie, Blay, Jean-Yves, Naquet, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296645/
https://www.ncbi.nlm.nih.gov/pubmed/34294128
http://dx.doi.org/10.1186/s13045-021-01125-y
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author Miallot, Richard
Galland, Franck
Millet, Virginie
Blay, Jean-Yves
Naquet, Philippe
author_facet Miallot, Richard
Galland, Franck
Millet, Virginie
Blay, Jean-Yves
Naquet, Philippe
author_sort Miallot, Richard
collection PubMed
description Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin, histological definition and underlying genetic history. Novel large-scale genomic and metabolomics approaches are now helping stratify their physiopathology. In this review, we show how various genetic alterations skew activation pathways and orient metabolic rewiring in sarcomas. We provide an update on the contribution of newly described mechanisms of metabolic regulation. We underscore mechanisms that are relevant to sarcomagenesis or shared with other cancers. We then discuss how diverse metabolic landscapes condition the tumor microenvironment, anti-sarcoma immune responses and prognosis. Finally, we review current attempts to control sarcoma growth using metabolite-targeting drugs.
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spelling pubmed-82966452021-07-22 Metabolic landscapes in sarcomas Miallot, Richard Galland, Franck Millet, Virginie Blay, Jean-Yves Naquet, Philippe J Hematol Oncol Review Metabolic rewiring offers novel therapeutic opportunities in cancer. Until recently, there was scant information regarding soft tissue sarcomas, due to their heterogeneous tissue origin, histological definition and underlying genetic history. Novel large-scale genomic and metabolomics approaches are now helping stratify their physiopathology. In this review, we show how various genetic alterations skew activation pathways and orient metabolic rewiring in sarcomas. We provide an update on the contribution of newly described mechanisms of metabolic regulation. We underscore mechanisms that are relevant to sarcomagenesis or shared with other cancers. We then discuss how diverse metabolic landscapes condition the tumor microenvironment, anti-sarcoma immune responses and prognosis. Finally, we review current attempts to control sarcoma growth using metabolite-targeting drugs. BioMed Central 2021-07-22 /pmc/articles/PMC8296645/ /pubmed/34294128 http://dx.doi.org/10.1186/s13045-021-01125-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Miallot, Richard
Galland, Franck
Millet, Virginie
Blay, Jean-Yves
Naquet, Philippe
Metabolic landscapes in sarcomas
title Metabolic landscapes in sarcomas
title_full Metabolic landscapes in sarcomas
title_fullStr Metabolic landscapes in sarcomas
title_full_unstemmed Metabolic landscapes in sarcomas
title_short Metabolic landscapes in sarcomas
title_sort metabolic landscapes in sarcomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296645/
https://www.ncbi.nlm.nih.gov/pubmed/34294128
http://dx.doi.org/10.1186/s13045-021-01125-y
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