Cargando…

Ultrasonography to detect cardiovascular damage in children with essential hypertension

BACKGROUND: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at earl...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Wei, Hou, Cui, Hou, Miao, Xu, Qiu-Qin, Wang, Hui, Gu, Pei-Pei, Sun, Ling, Lv, Hai-Tao, Ding, Yue-Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296659/
https://www.ncbi.nlm.nih.gov/pubmed/34289865
http://dx.doi.org/10.1186/s12947-021-00257-y
_version_ 1783725689538609152
author Liu, Wei
Hou, Cui
Hou, Miao
Xu, Qiu-Qin
Wang, Hui
Gu, Pei-Pei
Sun, Ling
Lv, Hai-Tao
Ding, Yue-Yue
author_facet Liu, Wei
Hou, Cui
Hou, Miao
Xu, Qiu-Qin
Wang, Hui
Gu, Pei-Pei
Sun, Ling
Lv, Hai-Tao
Ding, Yue-Yue
author_sort Liu, Wei
collection PubMed
description BACKGROUND: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography. METHODS: All patients with essential hypertension admitted from March 2020 to May 2021 were classified into simple hypertension (group 1, n = 34) and hypertension co-existing with obesity (group 2, n = 11) isolation. Meanwhile 32 healthy children were detected as control heathly group (group 3). We used pulse-wave Doppler to measure carotid–femoral pulse wave velocity (cfPWV), intimal–medial thickness (cIMT) and distensibility of carotid artery (CD). Cardiac structure and function (left atrial diameter [LAD], left ventricular mass [LVM], LVM index [LVMI], relative wall thicknes [RWT], end-diastolic left ventricular internal diameter [LVIDd], diastolic interventricular septum thickness [IVSd], diastolic left ventricular posterior wall thickness [LVPWd], root diameter of aorta [AO], E peak, A peak, E' peak, A' peak, E/E' ratio, and E/A ratio) were measured by echocardiography. RESULTS: The cfPWV of children in group 1 and group 2 were significantly higher than healthy children in group 3. Significant differences were observed in LVM, LVMI, RWT, LVIDd, IVSd, LVPWd, LAD, A peak, E' peak, A' peak, and E/E’ among three groups. CONCLUSION: Children and adolescents with essential hypertension demonstrate target organ damages in the heart and blood vessels.
format Online
Article
Text
id pubmed-8296659
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-82966592021-07-22 Ultrasonography to detect cardiovascular damage in children with essential hypertension Liu, Wei Hou, Cui Hou, Miao Xu, Qiu-Qin Wang, Hui Gu, Pei-Pei Sun, Ling Lv, Hai-Tao Ding, Yue-Yue Cardiovasc Ultrasound Research BACKGROUND: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography. METHODS: All patients with essential hypertension admitted from March 2020 to May 2021 were classified into simple hypertension (group 1, n = 34) and hypertension co-existing with obesity (group 2, n = 11) isolation. Meanwhile 32 healthy children were detected as control heathly group (group 3). We used pulse-wave Doppler to measure carotid–femoral pulse wave velocity (cfPWV), intimal–medial thickness (cIMT) and distensibility of carotid artery (CD). Cardiac structure and function (left atrial diameter [LAD], left ventricular mass [LVM], LVM index [LVMI], relative wall thicknes [RWT], end-diastolic left ventricular internal diameter [LVIDd], diastolic interventricular septum thickness [IVSd], diastolic left ventricular posterior wall thickness [LVPWd], root diameter of aorta [AO], E peak, A peak, E' peak, A' peak, E/E' ratio, and E/A ratio) were measured by echocardiography. RESULTS: The cfPWV of children in group 1 and group 2 were significantly higher than healthy children in group 3. Significant differences were observed in LVM, LVMI, RWT, LVIDd, IVSd, LVPWd, LAD, A peak, E' peak, A' peak, and E/E’ among three groups. CONCLUSION: Children and adolescents with essential hypertension demonstrate target organ damages in the heart and blood vessels. BioMed Central 2021-07-21 /pmc/articles/PMC8296659/ /pubmed/34289865 http://dx.doi.org/10.1186/s12947-021-00257-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Wei
Hou, Cui
Hou, Miao
Xu, Qiu-Qin
Wang, Hui
Gu, Pei-Pei
Sun, Ling
Lv, Hai-Tao
Ding, Yue-Yue
Ultrasonography to detect cardiovascular damage in children with essential hypertension
title Ultrasonography to detect cardiovascular damage in children with essential hypertension
title_full Ultrasonography to detect cardiovascular damage in children with essential hypertension
title_fullStr Ultrasonography to detect cardiovascular damage in children with essential hypertension
title_full_unstemmed Ultrasonography to detect cardiovascular damage in children with essential hypertension
title_short Ultrasonography to detect cardiovascular damage in children with essential hypertension
title_sort ultrasonography to detect cardiovascular damage in children with essential hypertension
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296659/
https://www.ncbi.nlm.nih.gov/pubmed/34289865
http://dx.doi.org/10.1186/s12947-021-00257-y
work_keys_str_mv AT liuwei ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT houcui ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT houmiao ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT xuqiuqin ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT wanghui ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT gupeipei ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT sunling ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT lvhaitao ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension
AT dingyueyue ultrasonographytodetectcardiovasculardamageinchildrenwithessentialhypertension