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Ultrasonography to detect cardiovascular damage in children with essential hypertension
BACKGROUND: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at earl...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296659/ https://www.ncbi.nlm.nih.gov/pubmed/34289865 http://dx.doi.org/10.1186/s12947-021-00257-y |
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author | Liu, Wei Hou, Cui Hou, Miao Xu, Qiu-Qin Wang, Hui Gu, Pei-Pei Sun, Ling Lv, Hai-Tao Ding, Yue-Yue |
author_facet | Liu, Wei Hou, Cui Hou, Miao Xu, Qiu-Qin Wang, Hui Gu, Pei-Pei Sun, Ling Lv, Hai-Tao Ding, Yue-Yue |
author_sort | Liu, Wei |
collection | PubMed |
description | BACKGROUND: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography. METHODS: All patients with essential hypertension admitted from March 2020 to May 2021 were classified into simple hypertension (group 1, n = 34) and hypertension co-existing with obesity (group 2, n = 11) isolation. Meanwhile 32 healthy children were detected as control heathly group (group 3). We used pulse-wave Doppler to measure carotid–femoral pulse wave velocity (cfPWV), intimal–medial thickness (cIMT) and distensibility of carotid artery (CD). Cardiac structure and function (left atrial diameter [LAD], left ventricular mass [LVM], LVM index [LVMI], relative wall thicknes [RWT], end-diastolic left ventricular internal diameter [LVIDd], diastolic interventricular septum thickness [IVSd], diastolic left ventricular posterior wall thickness [LVPWd], root diameter of aorta [AO], E peak, A peak, E' peak, A' peak, E/E' ratio, and E/A ratio) were measured by echocardiography. RESULTS: The cfPWV of children in group 1 and group 2 were significantly higher than healthy children in group 3. Significant differences were observed in LVM, LVMI, RWT, LVIDd, IVSd, LVPWd, LAD, A peak, E' peak, A' peak, and E/E’ among three groups. CONCLUSION: Children and adolescents with essential hypertension demonstrate target organ damages in the heart and blood vessels. |
format | Online Article Text |
id | pubmed-8296659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82966592021-07-22 Ultrasonography to detect cardiovascular damage in children with essential hypertension Liu, Wei Hou, Cui Hou, Miao Xu, Qiu-Qin Wang, Hui Gu, Pei-Pei Sun, Ling Lv, Hai-Tao Ding, Yue-Yue Cardiovasc Ultrasound Research BACKGROUND: Essential hypertension in adults may begin in childhood. The damages to the heart and blood vessels in children with essential hypertension are hidden and difficult to detect. We noninvasively examined changes in cardiovascular structure and function in children with hypertension at early stage using ultrasonography. METHODS: All patients with essential hypertension admitted from March 2020 to May 2021 were classified into simple hypertension (group 1, n = 34) and hypertension co-existing with obesity (group 2, n = 11) isolation. Meanwhile 32 healthy children were detected as control heathly group (group 3). We used pulse-wave Doppler to measure carotid–femoral pulse wave velocity (cfPWV), intimal–medial thickness (cIMT) and distensibility of carotid artery (CD). Cardiac structure and function (left atrial diameter [LAD], left ventricular mass [LVM], LVM index [LVMI], relative wall thicknes [RWT], end-diastolic left ventricular internal diameter [LVIDd], diastolic interventricular septum thickness [IVSd], diastolic left ventricular posterior wall thickness [LVPWd], root diameter of aorta [AO], E peak, A peak, E' peak, A' peak, E/E' ratio, and E/A ratio) were measured by echocardiography. RESULTS: The cfPWV of children in group 1 and group 2 were significantly higher than healthy children in group 3. Significant differences were observed in LVM, LVMI, RWT, LVIDd, IVSd, LVPWd, LAD, A peak, E' peak, A' peak, and E/E’ among three groups. CONCLUSION: Children and adolescents with essential hypertension demonstrate target organ damages in the heart and blood vessels. BioMed Central 2021-07-21 /pmc/articles/PMC8296659/ /pubmed/34289865 http://dx.doi.org/10.1186/s12947-021-00257-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Liu, Wei Hou, Cui Hou, Miao Xu, Qiu-Qin Wang, Hui Gu, Pei-Pei Sun, Ling Lv, Hai-Tao Ding, Yue-Yue Ultrasonography to detect cardiovascular damage in children with essential hypertension |
title | Ultrasonography to detect cardiovascular damage in children with essential hypertension |
title_full | Ultrasonography to detect cardiovascular damage in children with essential hypertension |
title_fullStr | Ultrasonography to detect cardiovascular damage in children with essential hypertension |
title_full_unstemmed | Ultrasonography to detect cardiovascular damage in children with essential hypertension |
title_short | Ultrasonography to detect cardiovascular damage in children with essential hypertension |
title_sort | ultrasonography to detect cardiovascular damage in children with essential hypertension |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296659/ https://www.ncbi.nlm.nih.gov/pubmed/34289865 http://dx.doi.org/10.1186/s12947-021-00257-y |
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