Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma

Used for a wide range of cancers, nivolumab has been reported to cause immune-related adverse events, including isolated adrenocorticotropic hormone deficiency (IAD). We report an 81-year-old woman with malignant mesothelioma who presented with abdominal pain after eight courses of nivolumab therapy...

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Autores principales: Hata, Koichi, Sakaguchi, Chikara, Tsuchiya, Michiko, Nagasaka, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296770/
https://www.ncbi.nlm.nih.gov/pubmed/34290022
http://dx.doi.org/10.1136/bcr-2021-243093
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author Hata, Koichi
Sakaguchi, Chikara
Tsuchiya, Michiko
Nagasaka, Yukio
author_facet Hata, Koichi
Sakaguchi, Chikara
Tsuchiya, Michiko
Nagasaka, Yukio
author_sort Hata, Koichi
collection PubMed
description Used for a wide range of cancers, nivolumab has been reported to cause immune-related adverse events, including isolated adrenocorticotropic hormone deficiency (IAD). We report an 81-year-old woman with malignant mesothelioma who presented with abdominal pain after eight courses of nivolumab therapy, leading to the diagnosis of nivolumab-induced IAD. We should consider adrenal insufficiency (AI) when a patient on nivolumab complains of abdominal pain and has no other explanatory findings. Infusion-resistant hypotension and hyponatraemia can further suggest AI.
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spelling pubmed-82967702021-08-12 Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma Hata, Koichi Sakaguchi, Chikara Tsuchiya, Michiko Nagasaka, Yukio BMJ Case Rep Case Report Used for a wide range of cancers, nivolumab has been reported to cause immune-related adverse events, including isolated adrenocorticotropic hormone deficiency (IAD). We report an 81-year-old woman with malignant mesothelioma who presented with abdominal pain after eight courses of nivolumab therapy, leading to the diagnosis of nivolumab-induced IAD. We should consider adrenal insufficiency (AI) when a patient on nivolumab complains of abdominal pain and has no other explanatory findings. Infusion-resistant hypotension and hyponatraemia can further suggest AI. BMJ Publishing Group 2021-07-21 /pmc/articles/PMC8296770/ /pubmed/34290022 http://dx.doi.org/10.1136/bcr-2021-243093 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Report
Hata, Koichi
Sakaguchi, Chikara
Tsuchiya, Michiko
Nagasaka, Yukio
Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma
title Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma
title_full Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma
title_fullStr Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma
title_full_unstemmed Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma
title_short Abdominal pain as an initial symptom of isolated ACTH deficiency induced by nivolumab in a patient with malignant mesothelioma
title_sort abdominal pain as an initial symptom of isolated acth deficiency induced by nivolumab in a patient with malignant mesothelioma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296770/
https://www.ncbi.nlm.nih.gov/pubmed/34290022
http://dx.doi.org/10.1136/bcr-2021-243093
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