Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction

Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before th...

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Autores principales: Wang, Cong-mei, Chen, Wei-can, Zhang, Yan, Lin, Shu, He, He-fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296910/
https://www.ncbi.nlm.nih.gov/pubmed/34305576
http://dx.doi.org/10.3389/fnagi.2021.702231
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author Wang, Cong-mei
Chen, Wei-can
Zhang, Yan
Lin, Shu
He, He-fan
author_facet Wang, Cong-mei
Chen, Wei-can
Zhang, Yan
Lin, Shu
He, He-fan
author_sort Wang, Cong-mei
collection PubMed
description Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before the operation. POCD affects the lives of patients and places an additional burden on patients and their families. Understanding the mechanism of sevoflurane-induced POCD may improve prevention and treatment of POCD. In this paper, we review the diagnosis of POCD, introduce animal models of POCD in clinical research, analyze the possible mechanisms of sevoflurane-induced POCD, and summarize advances in treatment for this condition.
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spelling pubmed-82969102021-07-23 Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction Wang, Cong-mei Chen, Wei-can Zhang, Yan Lin, Shu He, He-fan Front Aging Neurosci Neuroscience Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before the operation. POCD affects the lives of patients and places an additional burden on patients and their families. Understanding the mechanism of sevoflurane-induced POCD may improve prevention and treatment of POCD. In this paper, we review the diagnosis of POCD, introduce animal models of POCD in clinical research, analyze the possible mechanisms of sevoflurane-induced POCD, and summarize advances in treatment for this condition. Frontiers Media S.A. 2021-07-08 /pmc/articles/PMC8296910/ /pubmed/34305576 http://dx.doi.org/10.3389/fnagi.2021.702231 Text en Copyright © 2021 Wang, Chen, Zhang, Lin and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Cong-mei
Chen, Wei-can
Zhang, Yan
Lin, Shu
He, He-fan
Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
title Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
title_full Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
title_fullStr Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
title_full_unstemmed Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
title_short Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction
title_sort update on the mechanism and treatment of sevoflurane-induced postoperative cognitive dysfunction
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296910/
https://www.ncbi.nlm.nih.gov/pubmed/34305576
http://dx.doi.org/10.3389/fnagi.2021.702231
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