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Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults

Mexican-origin (MO) adults have among the highest rates of nonalcoholic fatty liver disease (NAFLD) placing them at increased risk of liver cancer. Evidence suggests that a single nucleotide polymorphism (SNP) in the PNPLA3 gene, rs738409, increases the risk and progression of NAFLD and may modify t...

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Autores principales: Morrill, Kristin E., Bland, Victoria L., Klimentidis, Yann C., Hingle, Melanie D., Thomson, Cynthia A., Garcia, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296936/
https://www.ncbi.nlm.nih.gov/pubmed/34280991
http://dx.doi.org/10.3390/ijerph18137055
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author Morrill, Kristin E.
Bland, Victoria L.
Klimentidis, Yann C.
Hingle, Melanie D.
Thomson, Cynthia A.
Garcia, David O.
author_facet Morrill, Kristin E.
Bland, Victoria L.
Klimentidis, Yann C.
Hingle, Melanie D.
Thomson, Cynthia A.
Garcia, David O.
author_sort Morrill, Kristin E.
collection PubMed
description Mexican-origin (MO) adults have among the highest rates of nonalcoholic fatty liver disease (NAFLD) placing them at increased risk of liver cancer. Evidence suggests that a single nucleotide polymorphism (SNP) in the PNPLA3 gene, rs738409, increases the risk and progression of NAFLD and may modify the relationship between certain dietary factors and liver steatosis. The purpose of this study was to identify whether interactions exist between specific dietary factors and rs738409 genotype status among MO adults in relation to levels of liver steatosis. We analyzed cross-sectional data from a sample of 288 MO adults. Participants completed at least two 24-h dietary recalls. Multiple linear regression was performed assuming an additive genetic model to test the main effects of several dietary variables on levels of hepatic steatosis, adjusting for covariates. To test for effect modification, the product of the genotype and the dietary variable was included as a covariate in the model. No significant association between dietary intake and level of hepatic steatosis was observed, nor any significant gene-diet interactions. Our findings suggest that dietary intake may have the same magnitude of protective or deleterious effect even among MO adults with high genetic risk for NAFLD and NAFLD progression.
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spelling pubmed-82969362021-07-23 Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults Morrill, Kristin E. Bland, Victoria L. Klimentidis, Yann C. Hingle, Melanie D. Thomson, Cynthia A. Garcia, David O. Int J Environ Res Public Health Article Mexican-origin (MO) adults have among the highest rates of nonalcoholic fatty liver disease (NAFLD) placing them at increased risk of liver cancer. Evidence suggests that a single nucleotide polymorphism (SNP) in the PNPLA3 gene, rs738409, increases the risk and progression of NAFLD and may modify the relationship between certain dietary factors and liver steatosis. The purpose of this study was to identify whether interactions exist between specific dietary factors and rs738409 genotype status among MO adults in relation to levels of liver steatosis. We analyzed cross-sectional data from a sample of 288 MO adults. Participants completed at least two 24-h dietary recalls. Multiple linear regression was performed assuming an additive genetic model to test the main effects of several dietary variables on levels of hepatic steatosis, adjusting for covariates. To test for effect modification, the product of the genotype and the dietary variable was included as a covariate in the model. No significant association between dietary intake and level of hepatic steatosis was observed, nor any significant gene-diet interactions. Our findings suggest that dietary intake may have the same magnitude of protective or deleterious effect even among MO adults with high genetic risk for NAFLD and NAFLD progression. MDPI 2021-07-01 /pmc/articles/PMC8296936/ /pubmed/34280991 http://dx.doi.org/10.3390/ijerph18137055 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morrill, Kristin E.
Bland, Victoria L.
Klimentidis, Yann C.
Hingle, Melanie D.
Thomson, Cynthia A.
Garcia, David O.
Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults
title Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults
title_full Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults
title_fullStr Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults
title_full_unstemmed Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults
title_short Assessing Interactions between PNPLA3 and Dietary Intake on Liver Steatosis in Mexican-Origin Adults
title_sort assessing interactions between pnpla3 and dietary intake on liver steatosis in mexican-origin adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296936/
https://www.ncbi.nlm.nih.gov/pubmed/34280991
http://dx.doi.org/10.3390/ijerph18137055
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