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Ambient Air Pollutions Are Associated with Vitamin D Status

Evidence on the effect of ambient air pollution on vitamin D is limited. This study aimed to examine the association of air pollution exposure with serum levels of 25-hydroxyvitamin D (25OHD) using UK Biobank health datasets. A total of 448,337 subjects were included in this analysis. Land Use Regre...

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Detalles Bibliográficos
Autores principales: Yang, Chenlu, Li, Dankang, Tian, Yaohua, Wang, Peiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297026/
https://www.ncbi.nlm.nih.gov/pubmed/34198962
http://dx.doi.org/10.3390/ijerph18136887
Descripción
Sumario:Evidence on the effect of ambient air pollution on vitamin D is limited. This study aimed to examine the association of air pollution exposure with serum levels of 25-hydroxyvitamin D (25OHD) using UK Biobank health datasets. A total of 448,337 subjects were included in this analysis. Land Use Regression was applied to assess individual exposures to particulate matter with diameters ≤2.5 µm (PM(2.5)), ≤10 µm (PM(10)), nitrogen dioxide (NO(2)), and nitrogen oxides (NO(x)). Linear regression models evaluated the associations between air pollutants and serum vitamin D levels after adjustment of a series of confounders. All analyzed air pollutants were negatively associated with serum vitamin 25OHD levels. After adjusting for potential confounders, a 10 μg/m(3) increase in concentrations of PM(2.5), PM(10), NO(x), and NO(2) was associated with −9.11 (95%CI: −13.25 to −4.97), −2.47 (95%CI: −4.51 to −0.43), −0.56 (95%CI: −0.82 to −0.30), and −1.64 (95%CI: −2.17 to −1.10) nmol/L decrease in serum vitamin 25OHD levels, respectively. Interaction analyses suggested that the effects of air pollution were more pronounced in females. In conclusion, long-term exposures to ambient PM(2.5), PM(10), NO(x), and NO(2) were associated with vitamin D status in a large UK cohort.