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Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab)
BACKGROUND: Metastatic colorectal cancer (mCRC) with wild type expression of RAS and RAF genes can be treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, such as cetuximab, in combination with chemotherapy. Skin toxicity represents the most serious and frequent side effe...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297050/ https://www.ncbi.nlm.nih.gov/pubmed/34349854 http://dx.doi.org/10.14740/wjon1381 |
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author | De Luca, Rossella Lo Coco, Gianluca Addeo, Raffaele Fattoruso, Silvia Ileana Sara Auriemma, Annunziata Paci, Roberta Mistretta, Ornella Epifanio, Maria Stella Salvato, Angela D’Agostino, Alberto Cicero, Giuseppe |
author_facet | De Luca, Rossella Lo Coco, Gianluca Addeo, Raffaele Fattoruso, Silvia Ileana Sara Auriemma, Annunziata Paci, Roberta Mistretta, Ornella Epifanio, Maria Stella Salvato, Angela D’Agostino, Alberto Cicero, Giuseppe |
author_sort | De Luca, Rossella |
collection | PubMed |
description | BACKGROUND: Metastatic colorectal cancer (mCRC) with wild type expression of RAS and RAF genes can be treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, such as cetuximab, in combination with chemotherapy. Skin toxicity represents the most serious and frequent side effect in these patients. Skin manifestations occur in approximately 80% of patients. In this study, we investigated the consequences on body image and quality of life (QoL) of patients with severe skin toxicity. METHODS: One hundred patients were enrolled with mCRC. All patients signed informed consent and completed questionnaires to assess QoL and body discomfort. Toxicity was assessed on Common Terminology Criteria for Adverse Events (CTCAEs). RESULTS: The greatest impact on QoL was represented by difficulties in managing skin rash-related side effects. Data showed a significant impact in psychological sphere and social relationships. CONCLUSIONS: Skin side effects, particularly rash, influence QoL and social relationships, compromising therapeutic compliance. |
format | Online Article Text |
id | pubmed-8297050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82970502021-08-03 Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab) De Luca, Rossella Lo Coco, Gianluca Addeo, Raffaele Fattoruso, Silvia Ileana Sara Auriemma, Annunziata Paci, Roberta Mistretta, Ornella Epifanio, Maria Stella Salvato, Angela D’Agostino, Alberto Cicero, Giuseppe World J Oncol Original Article BACKGROUND: Metastatic colorectal cancer (mCRC) with wild type expression of RAS and RAF genes can be treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, such as cetuximab, in combination with chemotherapy. Skin toxicity represents the most serious and frequent side effect in these patients. Skin manifestations occur in approximately 80% of patients. In this study, we investigated the consequences on body image and quality of life (QoL) of patients with severe skin toxicity. METHODS: One hundred patients were enrolled with mCRC. All patients signed informed consent and completed questionnaires to assess QoL and body discomfort. Toxicity was assessed on Common Terminology Criteria for Adverse Events (CTCAEs). RESULTS: The greatest impact on QoL was represented by difficulties in managing skin rash-related side effects. Data showed a significant impact in psychological sphere and social relationships. CONCLUSIONS: Skin side effects, particularly rash, influence QoL and social relationships, compromising therapeutic compliance. Elmer Press 2021-08 2021-07-10 /pmc/articles/PMC8297050/ /pubmed/34349854 http://dx.doi.org/10.14740/wjon1381 Text en Copyright 2021, De Luca et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article De Luca, Rossella Lo Coco, Gianluca Addeo, Raffaele Fattoruso, Silvia Ileana Sara Auriemma, Annunziata Paci, Roberta Mistretta, Ornella Epifanio, Maria Stella Salvato, Angela D’Agostino, Alberto Cicero, Giuseppe Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab) |
title | Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab) |
title_full | Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab) |
title_fullStr | Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab) |
title_full_unstemmed | Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab) |
title_short | Quality of Life in Patients With Severe Skin Reactions in Course of First-Generation Epidermal Growth Factor Receptor Inhibitors Monoclonal Antibodies (Our Experience With Cetuximab) |
title_sort | quality of life in patients with severe skin reactions in course of first-generation epidermal growth factor receptor inhibitors monoclonal antibodies (our experience with cetuximab) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297050/ https://www.ncbi.nlm.nih.gov/pubmed/34349854 http://dx.doi.org/10.14740/wjon1381 |
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