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Transgenic Expression of a Mutant Ribonuclease Regnase-1 in T Cells Disturbs T Cell Development and Functions

Regnase-1 is an RNA-binding protein with ribonuclease activities, and once induced it controls diverse immune responses by degrading mRNAs that encode inflammatory cytokines and costimulatory molecules, thus exerting potent anti-inflammatory functions. However, Regnase-1 is extremely sensitive to de...

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Detalles Bibliográficos
Autores principales:	Kong, Gangcheng, Dou, Yaling, Xiao, Xiang, Wang, Yixuan, Ming, Yingzi, Li, Xian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297167/ https://www.ncbi.nlm.nih.gov/pubmed/34305914 http://dx.doi.org/10.3389/fimmu.2021.682220

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