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A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients

Background: The main objective of this study was to analyze the evolution of autobiographical memory (both episodic and semantic) in patients with mild cognitive impairment, patients with Alzheimer’s disease, and a healthy control group. We compared these groups at two time points: first, at baselin...

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Autores principales: Meléndez, Juan C., Pitarque, Alfonso, Delhom, Iraida, Real, Elena, Abella, Mireia, Satorres, Encarnación
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297234/
https://www.ncbi.nlm.nih.gov/pubmed/34202299
http://dx.doi.org/10.3390/ijerph18136849
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author Meléndez, Juan C.
Pitarque, Alfonso
Delhom, Iraida
Real, Elena
Abella, Mireia
Satorres, Encarnación
author_facet Meléndez, Juan C.
Pitarque, Alfonso
Delhom, Iraida
Real, Elena
Abella, Mireia
Satorres, Encarnación
author_sort Meléndez, Juan C.
collection PubMed
description Background: The main objective of this study was to analyze the evolution of autobiographical memory (both episodic and semantic) in patients with mild cognitive impairment, patients with Alzheimer’s disease, and a healthy control group. We compared these groups at two time points: first, at baseline, and in a follow-up after 18 months. Method: Twenty-six healthy older adults, 17 patients with mild amnestic cognitive impairment, and 16 patients with Alzheimer’s disease, matched on age and educational level, were evaluated at both time points with the Autobiographical Memory Interview. Results: The results showed significant longitudinal deterioration in episodic and semantic autobiographical memory in patients with mild cognitive impairment and in patients with Alzheimer’s disease, but not in healthy older adults. Conclusions: The deterioration of episodic and semantic autobiographical memory in AD is confirmed; however, although the episodic was impaired in aMCI, a pattern that evolved toward deterioration over a period of eighteen months was observed for the semantic autobiographical memory.
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spelling pubmed-82972342021-07-23 A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients Meléndez, Juan C. Pitarque, Alfonso Delhom, Iraida Real, Elena Abella, Mireia Satorres, Encarnación Int J Environ Res Public Health Article Background: The main objective of this study was to analyze the evolution of autobiographical memory (both episodic and semantic) in patients with mild cognitive impairment, patients with Alzheimer’s disease, and a healthy control group. We compared these groups at two time points: first, at baseline, and in a follow-up after 18 months. Method: Twenty-six healthy older adults, 17 patients with mild amnestic cognitive impairment, and 16 patients with Alzheimer’s disease, matched on age and educational level, were evaluated at both time points with the Autobiographical Memory Interview. Results: The results showed significant longitudinal deterioration in episodic and semantic autobiographical memory in patients with mild cognitive impairment and in patients with Alzheimer’s disease, but not in healthy older adults. Conclusions: The deterioration of episodic and semantic autobiographical memory in AD is confirmed; however, although the episodic was impaired in aMCI, a pattern that evolved toward deterioration over a period of eighteen months was observed for the semantic autobiographical memory. MDPI 2021-06-25 /pmc/articles/PMC8297234/ /pubmed/34202299 http://dx.doi.org/10.3390/ijerph18136849 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meléndez, Juan C.
Pitarque, Alfonso
Delhom, Iraida
Real, Elena
Abella, Mireia
Satorres, Encarnación
A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients
title A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients
title_full A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients
title_fullStr A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients
title_full_unstemmed A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients
title_short A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients
title_sort longitudinal study of episodic and semantic autobiographical memory in amci and alzheimer’s disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297234/
https://www.ncbi.nlm.nih.gov/pubmed/34202299
http://dx.doi.org/10.3390/ijerph18136849
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