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Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades

Objectives: The aim of this study was to explore the trend of ischemic heart disease (IHD) admission and the prescriptions of IHD medications in England and Wales. Methods: A secular trends study was conducted during the period of 1999 to 2019. We extracted hospital admission data for patients from...

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Autores principales: Hemmo, Sara Ibrahim, Naser, Abdallah Y., Alwafi, Hassan, Mansour, Munthir M., Alanazi, Abeer F. R., Jalal, Zahraa, Alsairafi, Zahra Khalil, Paudyal, Vibhu, Alomari, Esra’a, Al-Momani, Hamzeh, Salawati, Emad M., Samannodi, Mohammed, Dairi, Mohammad S., Al Bawab, Abdel Qader, Mustafa Ali, Moaath K., Alkharabsheh, Saqer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297245/
https://www.ncbi.nlm.nih.gov/pubmed/34280978
http://dx.doi.org/10.3390/ijerph18137041
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author Hemmo, Sara Ibrahim
Naser, Abdallah Y.
Alwafi, Hassan
Mansour, Munthir M.
Alanazi, Abeer F. R.
Jalal, Zahraa
Alsairafi, Zahra Khalil
Paudyal, Vibhu
Alomari, Esra’a
Al-Momani, Hamzeh
Salawati, Emad M.
Samannodi, Mohammed
Dairi, Mohammad S.
Al Bawab, Abdel Qader
Mustafa Ali, Moaath K.
Alkharabsheh, Saqer
author_facet Hemmo, Sara Ibrahim
Naser, Abdallah Y.
Alwafi, Hassan
Mansour, Munthir M.
Alanazi, Abeer F. R.
Jalal, Zahraa
Alsairafi, Zahra Khalil
Paudyal, Vibhu
Alomari, Esra’a
Al-Momani, Hamzeh
Salawati, Emad M.
Samannodi, Mohammed
Dairi, Mohammad S.
Al Bawab, Abdel Qader
Mustafa Ali, Moaath K.
Alkharabsheh, Saqer
author_sort Hemmo, Sara Ibrahim
collection PubMed
description Objectives: The aim of this study was to explore the trend of ischemic heart disease (IHD) admission and the prescriptions of IHD medications in England and Wales. Methods: A secular trends study was conducted during the period of 1999 to 2019. We extracted hospital admission data for patients from all age groups from the Hospital Episode Statistics database in England and the Patient Episode Database for Wales. Prescriptions of IHD medications were extracted from the Prescription Cost Analysis database from 2004 to 2019. The chi-squared test was used to assess the difference between the admission rates and the difference between IHD medication prescription rates. The trends in IHD-related hospital admission and IHD-related medication prescription were assessed using a Poisson model. The correlation between hospital admissions for IHD and its IHD medication-related prescriptions was assessed using the Pearson correlation coefficient. Results: Our study detected a significant increase in the rate of cardiovascular disease (CVD) medication prescriptions in England and Wales, representing a rise in the CVD medications prescription rate of 41.8% (from 539,334.95 (95% CI = 539,286.30–539,383.59) in 2004 to 764,584.55 (95% CI = 764,545.55–764,623.56) in 2019 prescriptions per 100,000 persons), with a mean increase of 2.8% per year during the past 15 years. This increase was connected with a reduction in the IHD hospital admission rate by 15.4% (from 838.50 (95% CI = 836.05–840.94) in 2004 to 709.78 (95% CI = 707.65–711.92) in 2019 per 100,000 persons, trend test, p < 0.01), with a mean decrease of 1.02% per year during the past 15 years and by 5% (from 747.43 (95% CI = 745.09–749.77) in 1999 to 709.78 (95% CI = 707.65–711.92) in 2019 per 100,000 persons, trend test, p < 0.01) with a mean decrease of 0.25% per year during the past two decades in England and Wales. Conclusion: The rate of hospitalisation due to IHD has decreased in England and Wales during the past two decades. Hospitalisation due to IHD was strongly and negatively correlated with the increase in the rates of dispensing of IHD-related medications. Other factors contributing to this decline could be the increase in controlling IHD risk factors during the past few years. Future studies exploring other risk factors that are associated with IHD hospitalisation are warranted.
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spelling pubmed-82972452021-07-23 Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades Hemmo, Sara Ibrahim Naser, Abdallah Y. Alwafi, Hassan Mansour, Munthir M. Alanazi, Abeer F. R. Jalal, Zahraa Alsairafi, Zahra Khalil Paudyal, Vibhu Alomari, Esra’a Al-Momani, Hamzeh Salawati, Emad M. Samannodi, Mohammed Dairi, Mohammad S. Al Bawab, Abdel Qader Mustafa Ali, Moaath K. Alkharabsheh, Saqer Int J Environ Res Public Health Article Objectives: The aim of this study was to explore the trend of ischemic heart disease (IHD) admission and the prescriptions of IHD medications in England and Wales. Methods: A secular trends study was conducted during the period of 1999 to 2019. We extracted hospital admission data for patients from all age groups from the Hospital Episode Statistics database in England and the Patient Episode Database for Wales. Prescriptions of IHD medications were extracted from the Prescription Cost Analysis database from 2004 to 2019. The chi-squared test was used to assess the difference between the admission rates and the difference between IHD medication prescription rates. The trends in IHD-related hospital admission and IHD-related medication prescription were assessed using a Poisson model. The correlation between hospital admissions for IHD and its IHD medication-related prescriptions was assessed using the Pearson correlation coefficient. Results: Our study detected a significant increase in the rate of cardiovascular disease (CVD) medication prescriptions in England and Wales, representing a rise in the CVD medications prescription rate of 41.8% (from 539,334.95 (95% CI = 539,286.30–539,383.59) in 2004 to 764,584.55 (95% CI = 764,545.55–764,623.56) in 2019 prescriptions per 100,000 persons), with a mean increase of 2.8% per year during the past 15 years. This increase was connected with a reduction in the IHD hospital admission rate by 15.4% (from 838.50 (95% CI = 836.05–840.94) in 2004 to 709.78 (95% CI = 707.65–711.92) in 2019 per 100,000 persons, trend test, p < 0.01), with a mean decrease of 1.02% per year during the past 15 years and by 5% (from 747.43 (95% CI = 745.09–749.77) in 1999 to 709.78 (95% CI = 707.65–711.92) in 2019 per 100,000 persons, trend test, p < 0.01) with a mean decrease of 0.25% per year during the past two decades in England and Wales. Conclusion: The rate of hospitalisation due to IHD has decreased in England and Wales during the past two decades. Hospitalisation due to IHD was strongly and negatively correlated with the increase in the rates of dispensing of IHD-related medications. Other factors contributing to this decline could be the increase in controlling IHD risk factors during the past few years. Future studies exploring other risk factors that are associated with IHD hospitalisation are warranted. MDPI 2021-07-01 /pmc/articles/PMC8297245/ /pubmed/34280978 http://dx.doi.org/10.3390/ijerph18137041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hemmo, Sara Ibrahim
Naser, Abdallah Y.
Alwafi, Hassan
Mansour, Munthir M.
Alanazi, Abeer F. R.
Jalal, Zahraa
Alsairafi, Zahra Khalil
Paudyal, Vibhu
Alomari, Esra’a
Al-Momani, Hamzeh
Salawati, Emad M.
Samannodi, Mohammed
Dairi, Mohammad S.
Al Bawab, Abdel Qader
Mustafa Ali, Moaath K.
Alkharabsheh, Saqer
Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades
title Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades
title_full Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades
title_fullStr Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades
title_full_unstemmed Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades
title_short Hospital Admissions Due to Ischemic Heart Diseases and Prescriptions of Cardiovascular Diseases Medications in England and Wales in the Past Two Decades
title_sort hospital admissions due to ischemic heart diseases and prescriptions of cardiovascular diseases medications in england and wales in the past two decades
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297245/
https://www.ncbi.nlm.nih.gov/pubmed/34280978
http://dx.doi.org/10.3390/ijerph18137041
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