Cargando…
Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy
Despite the decline in tuberculosis incidence (TB) in Germany, health workers (HW) are at greater risk of becoming infected with Mycobacterium tuberculosis. To date, little is known about the risk of progression of latent tuberculosis infections (LTBI) and the use of Tuberculosis Preventive Therapy...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297349/ https://www.ncbi.nlm.nih.gov/pubmed/34280988 http://dx.doi.org/10.3390/ijerph18137053 |
_version_ | 1783725840497901568 |
---|---|
author | Zielinski, Nika Stranzinger, Johanna Zeeb, Hajo Kersten, Jan Felix Nienhaus, Albert |
author_facet | Zielinski, Nika Stranzinger, Johanna Zeeb, Hajo Kersten, Jan Felix Nienhaus, Albert |
author_sort | Zielinski, Nika |
collection | PubMed |
description | Despite the decline in tuberculosis incidence (TB) in Germany, health workers (HW) are at greater risk of becoming infected with Mycobacterium tuberculosis. To date, little is known about the risk of progression of latent tuberculosis infections (LTBI) and the use of Tuberculosis Preventive Therapy (TPT) among HW. Routine data from the German Statutory Institution for Accident Insurance and Prevention for Health and Welfare Services (BGW) were analysed and a retrospective survey was conducted. A self-administered questionnaire was sent to 1711 HW who had received recognition of an LTBI as an occupational disease between the years 2009 and 2018. The response rate was 42.3% after correcting for those with no actual address (20.4%). We included 575 HW in the data analysis of the retrospective survey. The cumulative incidence of progression, the incidence density and the associated 95% confidence interval (95% CI) were calculated. Three progressive cases were identified in the analysis of the routine data. In the survey cohort, three HW developed TB during the observation period of 5.4 years on average (standard deviation: 2.8 years; interquartile range: 5.0 years). The cumulative TB incidence was 0.52% in the survey group (95% CI: 0.14% to 1.65%). The incidence density was 0.97 cases per 1000 person years (95% CI: 0.25 to 3.10). One-third of the respondents underwent TPT. Significant differences were observed between age and activity groups in the use of TPT, but not between the genders, year of diagnosis or the reason for performing the screening. The data indicate that the risk of progression of an LTBI is low for HW. However, one-third of the HW had undergone TPT. Information about the expected progression risk is important so that it can be weighed against the risk of side effects of TPT. |
format | Online Article Text |
id | pubmed-8297349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82973492021-07-23 Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy Zielinski, Nika Stranzinger, Johanna Zeeb, Hajo Kersten, Jan Felix Nienhaus, Albert Int J Environ Res Public Health Article Despite the decline in tuberculosis incidence (TB) in Germany, health workers (HW) are at greater risk of becoming infected with Mycobacterium tuberculosis. To date, little is known about the risk of progression of latent tuberculosis infections (LTBI) and the use of Tuberculosis Preventive Therapy (TPT) among HW. Routine data from the German Statutory Institution for Accident Insurance and Prevention for Health and Welfare Services (BGW) were analysed and a retrospective survey was conducted. A self-administered questionnaire was sent to 1711 HW who had received recognition of an LTBI as an occupational disease between the years 2009 and 2018. The response rate was 42.3% after correcting for those with no actual address (20.4%). We included 575 HW in the data analysis of the retrospective survey. The cumulative incidence of progression, the incidence density and the associated 95% confidence interval (95% CI) were calculated. Three progressive cases were identified in the analysis of the routine data. In the survey cohort, three HW developed TB during the observation period of 5.4 years on average (standard deviation: 2.8 years; interquartile range: 5.0 years). The cumulative TB incidence was 0.52% in the survey group (95% CI: 0.14% to 1.65%). The incidence density was 0.97 cases per 1000 person years (95% CI: 0.25 to 3.10). One-third of the respondents underwent TPT. Significant differences were observed between age and activity groups in the use of TPT, but not between the genders, year of diagnosis or the reason for performing the screening. The data indicate that the risk of progression of an LTBI is low for HW. However, one-third of the HW had undergone TPT. Information about the expected progression risk is important so that it can be weighed against the risk of side effects of TPT. MDPI 2021-07-01 /pmc/articles/PMC8297349/ /pubmed/34280988 http://dx.doi.org/10.3390/ijerph18137053 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zielinski, Nika Stranzinger, Johanna Zeeb, Hajo Kersten, Jan Felix Nienhaus, Albert Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy |
title | Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy |
title_full | Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy |
title_fullStr | Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy |
title_full_unstemmed | Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy |
title_short | Latent Tuberculosis Infection among Health Workers in Germany—A Retrospective Study on Progression Risk and Use of Preventive Therapy |
title_sort | latent tuberculosis infection among health workers in germany—a retrospective study on progression risk and use of preventive therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297349/ https://www.ncbi.nlm.nih.gov/pubmed/34280988 http://dx.doi.org/10.3390/ijerph18137053 |
work_keys_str_mv | AT zielinskinika latenttuberculosisinfectionamonghealthworkersingermanyaretrospectivestudyonprogressionriskanduseofpreventivetherapy AT stranzingerjohanna latenttuberculosisinfectionamonghealthworkersingermanyaretrospectivestudyonprogressionriskanduseofpreventivetherapy AT zeebhajo latenttuberculosisinfectionamonghealthworkersingermanyaretrospectivestudyonprogressionriskanduseofpreventivetherapy AT kerstenjanfelix latenttuberculosisinfectionamonghealthworkersingermanyaretrospectivestudyonprogressionriskanduseofpreventivetherapy AT nienhausalbert latenttuberculosisinfectionamonghealthworkersingermanyaretrospectivestudyonprogressionriskanduseofpreventivetherapy |