Cargando…

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Quadruple aberrant hyperphosphorylated tau (p-τ), amyloid-β peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ≤40y autopsies in Metropolitan Mexico City (MMC), and p-τ is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Calderón-Garcidueñas, Lilian, Rajkumar, Ravi Philip, Stommel, Elijah W., Kulesza, Randy, Mansour, Yusra, Rico-Villanueva, Adriana, Flores-Vázquez, Jorge Orlando, Brito-Aguilar, Rafael, Ramírez-Sánchez, Silvia, García-Alonso, Griselda, Chávez-Franco, Diana A., Luévano-Castro, Samuel C., García-Rojas, Edgar, Revueltas-Ficachi, Paula, Villarreal-Ríos, Rodolfo, Mukherjee, Partha S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297352/ https://www.ncbi.nlm.nih.gov/pubmed/34206224 http://dx.doi.org/10.3390/ijerph18136689

Ejemplares similares

TDP-43 CSF Concentrations Increase Exponentially with Age in Metropolitan Mexico City Young Urbanites Highly Exposed to PM(2.5) and Ultrafine Particles and Historically Showing Alzheimer and Parkinson’s Hallmarks. Brain TDP-43 Pathology in MMC Residents Is Associated with High Cisternal CSF TDP-43 Concentrations
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2022)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

Particulate Air Pollution and Risk of Neuropsychiatric Outcomes. What We Breathe, Swallow, and Put on Our Skin Matters
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2021)

Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation
por: Li, Huei-Ying, et al.
Publicado: (2011)

Sleep matters: Neurodegeneration spectrum heterogeneity, combustion and friction ultrafine particles, industrial nanoparticle pollution, and sleep disorders—Denial is not an option
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2023)

Hemispheric Cortical, Cerebellar and Caudate Atrophy Associated to Cognitive Impairment in Metropolitan Mexico City Young Adults Exposed to Fine Particulate Matter Air Pollution
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2022)

Environmentally Toxic Solid Nanoparticles in Noradrenergic and Dopaminergic Nuclei and Cerebellum of Metropolitan Mexico City Children and Young Adults with Neural Quadruple Misfolded Protein Pathologies and High Exposures to Nano Particulate Matter
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2022)

Detection of hyperphosphorylated tau protein and α-synuclein in spinal cord of patients with Alzheimer’s disease
por: Guo, Yanjun, et al.
Publicado: (2016)

The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
por: Zhang, Jianbin, et al.
Publicado: (2012)

Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
por: Tarutani, Airi, et al.
Publicado: (2022)

Metals, Nanoparticles, Particulate Matter, and Cognitive Decline
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2022)

Intranasal NAP (davunetide) decreases tau hyperphosphorylation and moderately improves behavioral deficits in mice overexpressing α-synuclein
por: Magen, Iddo, et al.
Publicado: (2014)

TDP-43 Potentiates Alpha-synuclein Toxicity to Dopaminergic Neurons in Transgenic Mice
por: Tian, Tian, et al.
Publicado: (2011)

Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation
por: Peled, Sivan, et al.
Publicado: (2017)

Correction to: Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
por: Tarutani, Airi, et al.
Publicado: (2022)

Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation
por: Li, Gaifen, et al.
Publicado: (2022)

A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk
por: Re, Diane B., et al.
Publicado: (2022)

A Microplate-Based Approach to Map Interactions between TDP-43 and α-Synuclein
por: Jamerlan, Angelo M., et al.
Publicado: (2022)

Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein
por: Dhakal, Shailendra, et al.
Publicado: (2022)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

Quadruple Pregnancy
por: Arthur, M.
Publicado: (1885)

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity
por: Tariq, Amber, et al.
Publicado: (2019)

Hyperphosphorylated PTEN exerts oncogenic properties
por: van Ree, Janine H., et al.
Publicado: (2023)

Malformaciones utrinas y su tratamiento quirúrgio : revisión bibliográfica/
por: Morales Ficachi, Esteban
Publicado: (1992)

Editorial: The role of the brainstem and cerebellum in autism and related neurodevelopmental disorders (DD)
por: London, Eric, et al.
Publicado: (2022)

Triple and quadruple jets
por: Kunszt, Zoltán
Publicado: (1984)

Case of Quadruple Birth
por: Wilson, James
Publicado: (1866)

Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure
por: Chaves, Rodrigo S, et al.
Publicado: (2010)

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
por: Melov, Simon, et al.
Publicado: (2007)

Hyperphosphorylated tau in young and middle-aged subjects
por: Elobeid, Adila, et al.
Publicado: (2011)

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
por: Ozdemir, Ahmet Yunus, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Immunological memory to hyperphosphorylated tau in asymptomatic individuals
por: Pascual, Gabriel, et al.
Publicado: (2017)

AKT Hyperphosphorylation and T Cell Exhaustion in Down Syndrome
por: Peeters, Daphne, et al.
Publicado: (2022)

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated
por: Barthélemy, Nicolas R., et al.
Publicado: (2022)

A rare variation of the glossopharyngeal nerve
por: Mansour, Yusra, et al.
Publicado: (2021)

Noradrenergic axons hitch hiking along the human abducens nerve
por: Mansour, Yusra, et al.
Publicado: (2023)

Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young
por: Calderón-Garcidueñas, Lilian, et al.
Publicado: (2020)

Pericellular Innervation of Neurons Expressing Abnormally Hyperphosphorylated Tau in the Hippocampal Formation of Alzheimer's Disease Patients
por: Blazquez-Llorca, Lidia, et al.
Publicado: (2010)

Different 8-Hydroxyquinolines Protect Models of TDP-43 Protein, α-Synuclein, and Polyglutamine Proteotoxicity through Distinct Mechanisms
por: Tardiff, Daniel F., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_n7clndd8cchjgkgbbe4cgeo9tt