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The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects

Liver fibrosis might be linked to the prevalence of chronic kidney disease (CKD). However, there is little information about the association between liver fibrosis and decreased kidney function in middle-aged and older subjects. We aimed to evaluate the influence of liver fibrosis on the incidence o...

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Autores principales: Kotoku, Kazuko, Michishita, Ryoma, Matsuda, Takuro, Kawakami, Shotaro, Morito, Natsumi, Uehara, Yoshinari, Higaki, Yasuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297372/
https://www.ncbi.nlm.nih.gov/pubmed/34209974
http://dx.doi.org/10.3390/ijerph18136980
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author Kotoku, Kazuko
Michishita, Ryoma
Matsuda, Takuro
Kawakami, Shotaro
Morito, Natsumi
Uehara, Yoshinari
Higaki, Yasuki
author_facet Kotoku, Kazuko
Michishita, Ryoma
Matsuda, Takuro
Kawakami, Shotaro
Morito, Natsumi
Uehara, Yoshinari
Higaki, Yasuki
author_sort Kotoku, Kazuko
collection PubMed
description Liver fibrosis might be linked to the prevalence of chronic kidney disease (CKD). However, there is little information about the association between liver fibrosis and decreased kidney function in middle-aged and older subjects. We aimed to evaluate the influence of liver fibrosis on the incidence or prevalence of CKD stage 3–5 in a retrospective cross-sectional study (Study 1, n = 806) and a 6-year longitudinal study (Study 2, n = 380) of middle-aged and older subjects. We evaluated liver fibrosis using the Fibrosis-4 (FIB-4) index and kidney function using the estimated glomerular filtration rate (eGFR) of all subjects. All subjects were divided into four groups on the basis of their FIB-4 score quartiles (low to high). In the Jonckheere–Terpstra trend test of Study 1, the eGFR decreased significantly from the lowest group to the highest group (p < 0.001). The Kaplan–Meier survival curve in Study 2 showed that the cumulative prevalence of CKD stage 3–5 was higher in the third quartile than the other quartiles. Our results suggest that liver fibrosis could be a useful indicator for the prevalence of CKD, even within a relatively healthy population, although liver fibrosis was not an independent risk factor.
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spelling pubmed-82973722021-07-23 The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects Kotoku, Kazuko Michishita, Ryoma Matsuda, Takuro Kawakami, Shotaro Morito, Natsumi Uehara, Yoshinari Higaki, Yasuki Int J Environ Res Public Health Article Liver fibrosis might be linked to the prevalence of chronic kidney disease (CKD). However, there is little information about the association between liver fibrosis and decreased kidney function in middle-aged and older subjects. We aimed to evaluate the influence of liver fibrosis on the incidence or prevalence of CKD stage 3–5 in a retrospective cross-sectional study (Study 1, n = 806) and a 6-year longitudinal study (Study 2, n = 380) of middle-aged and older subjects. We evaluated liver fibrosis using the Fibrosis-4 (FIB-4) index and kidney function using the estimated glomerular filtration rate (eGFR) of all subjects. All subjects were divided into four groups on the basis of their FIB-4 score quartiles (low to high). In the Jonckheere–Terpstra trend test of Study 1, the eGFR decreased significantly from the lowest group to the highest group (p < 0.001). The Kaplan–Meier survival curve in Study 2 showed that the cumulative prevalence of CKD stage 3–5 was higher in the third quartile than the other quartiles. Our results suggest that liver fibrosis could be a useful indicator for the prevalence of CKD, even within a relatively healthy population, although liver fibrosis was not an independent risk factor. MDPI 2021-06-29 /pmc/articles/PMC8297372/ /pubmed/34209974 http://dx.doi.org/10.3390/ijerph18136980 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kotoku, Kazuko
Michishita, Ryoma
Matsuda, Takuro
Kawakami, Shotaro
Morito, Natsumi
Uehara, Yoshinari
Higaki, Yasuki
The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects
title The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects
title_full The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects
title_fullStr The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects
title_full_unstemmed The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects
title_short The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects
title_sort association between decreased kidney function and fib-4 index value, as indirect liver fibrosis indicator, in middle-aged and older subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297372/
https://www.ncbi.nlm.nih.gov/pubmed/34209974
http://dx.doi.org/10.3390/ijerph18136980
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