Cargando…
Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents
The present study reports the generation of 2-hydroxyethyl starch microparticles for co-delivery and controlled release of multiple agents. The obtained microparticles are characterized by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, e...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297403/ https://www.ncbi.nlm.nih.gov/pubmed/34286634 http://dx.doi.org/10.1080/10717544.2021.1955043 |
_version_ | 1783725853501292544 |
---|---|
author | Obireddy, Sreekanth Reddy Lai, Wing-Fu |
author_facet | Obireddy, Sreekanth Reddy Lai, Wing-Fu |
author_sort | Obireddy, Sreekanth Reddy |
collection | PubMed |
description | The present study reports the generation of 2-hydroxyethyl starch microparticles for co-delivery and controlled release of multiple agents. The obtained microparticles are characterized by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. By using ofloxacin and ketoprofen as drug models, the release sustainability of the microparticles is examined at pH 1.2, 5.4, and 6.8 at 37 °C, with Fickian diffusion being found to be the major mechanism controlling the kinetics of drug release. Upon being loaded with the drug models, the microparticles show high efficiency in acting against Escherichia coli and Bacillus cereus. The results suggest that our reported microparticles warrant further development for applications in which co-administration of multiple bioactive agents is required. |
format | Online Article Text |
id | pubmed-8297403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-82974032021-08-03 Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents Obireddy, Sreekanth Reddy Lai, Wing-Fu Drug Deliv Research Article The present study reports the generation of 2-hydroxyethyl starch microparticles for co-delivery and controlled release of multiple agents. The obtained microparticles are characterized by using Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. By using ofloxacin and ketoprofen as drug models, the release sustainability of the microparticles is examined at pH 1.2, 5.4, and 6.8 at 37 °C, with Fickian diffusion being found to be the major mechanism controlling the kinetics of drug release. Upon being loaded with the drug models, the microparticles show high efficiency in acting against Escherichia coli and Bacillus cereus. The results suggest that our reported microparticles warrant further development for applications in which co-administration of multiple bioactive agents is required. Taylor & Francis 2021-07-21 /pmc/articles/PMC8297403/ /pubmed/34286634 http://dx.doi.org/10.1080/10717544.2021.1955043 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Obireddy, Sreekanth Reddy Lai, Wing-Fu Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents |
title | Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents |
title_full | Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents |
title_fullStr | Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents |
title_full_unstemmed | Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents |
title_short | Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents |
title_sort | preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297403/ https://www.ncbi.nlm.nih.gov/pubmed/34286634 http://dx.doi.org/10.1080/10717544.2021.1955043 |
work_keys_str_mv | AT obireddysreekanthreddy preparationandcharacterizationof2hydroxyethylstarchmicroparticlesforcodeliveryofmultiplebioactiveagents AT laiwingfu preparationandcharacterizationof2hydroxyethylstarchmicroparticlesforcodeliveryofmultiplebioactiveagents |