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Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers

Colorectal cancer ranks within the top three cancers both in terms of incidence as well as deaths. Metastasis is often the major cause of mortality and liver is the primary and most common site to which colorectal cancers metastasize. We tested the prognostic ability of a long non-coding RNA (lncRNA...

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Autores principales: Liu, Fang, Song, Zhen-Mei, Wang, Xiao-Di, Du, Shi-Yu, Peng, Na, Zhou, Jing-Rui, Zhang, Ming-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297503/
https://www.ncbi.nlm.nih.gov/pubmed/34307387
http://dx.doi.org/10.3389/fcell.2021.707115
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author Liu, Fang
Song, Zhen-Mei
Wang, Xiao-Di
Du, Shi-Yu
Peng, Na
Zhou, Jing-Rui
Zhang, Ming-Gang
author_facet Liu, Fang
Song, Zhen-Mei
Wang, Xiao-Di
Du, Shi-Yu
Peng, Na
Zhou, Jing-Rui
Zhang, Ming-Gang
author_sort Liu, Fang
collection PubMed
description Colorectal cancer ranks within the top three cancers both in terms of incidence as well as deaths. Metastasis is often the major cause of mortality and liver is the primary and most common site to which colorectal cancers metastasize. We tested the prognostic ability of a long non-coding RNA (lncRNA) signature in liver metastatic colorectal cancers. We first evaluated expression levels of several lncRNAs in eight excised liver metastases from primary colorectal cancers and found significantly upregulated lncRNAs HOTAIR and MALAT1 along with significantly downregulated LOC285194. We further compared the expression levels of HOTAIR, MALAT1 and LOC285194 in primary colorectal tumors at the time of initial diagnosis and correlated them with disease progression and liver metastasis. HOTAIR and MALAT1 were significantly upregulated and LOC285194 was significantly downregulated in twelve patients who were diagnosed with liver metastasis within 5 years of initial diagnosis, compared to the five patients with no metastasis. A positive signature comprising of high HOTAIR/MALAT1 and low LOC285194 also correlated with progression to higher grade tumors. Thus, the lncRNA signature comprising of high HOTAIR/MALAT1 and low LOC285194 could be a prognostic signature for liver metastasis as well as overall poor survival.
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spelling pubmed-82975032021-07-23 Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers Liu, Fang Song, Zhen-Mei Wang, Xiao-Di Du, Shi-Yu Peng, Na Zhou, Jing-Rui Zhang, Ming-Gang Front Cell Dev Biol Cell and Developmental Biology Colorectal cancer ranks within the top three cancers both in terms of incidence as well as deaths. Metastasis is often the major cause of mortality and liver is the primary and most common site to which colorectal cancers metastasize. We tested the prognostic ability of a long non-coding RNA (lncRNA) signature in liver metastatic colorectal cancers. We first evaluated expression levels of several lncRNAs in eight excised liver metastases from primary colorectal cancers and found significantly upregulated lncRNAs HOTAIR and MALAT1 along with significantly downregulated LOC285194. We further compared the expression levels of HOTAIR, MALAT1 and LOC285194 in primary colorectal tumors at the time of initial diagnosis and correlated them with disease progression and liver metastasis. HOTAIR and MALAT1 were significantly upregulated and LOC285194 was significantly downregulated in twelve patients who were diagnosed with liver metastasis within 5 years of initial diagnosis, compared to the five patients with no metastasis. A positive signature comprising of high HOTAIR/MALAT1 and low LOC285194 also correlated with progression to higher grade tumors. Thus, the lncRNA signature comprising of high HOTAIR/MALAT1 and low LOC285194 could be a prognostic signature for liver metastasis as well as overall poor survival. Frontiers Media S.A. 2021-07-08 /pmc/articles/PMC8297503/ /pubmed/34307387 http://dx.doi.org/10.3389/fcell.2021.707115 Text en Copyright © 2021 Liu, Song, Wang, Du, Peng, Zhou and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Fang
Song, Zhen-Mei
Wang, Xiao-Di
Du, Shi-Yu
Peng, Na
Zhou, Jing-Rui
Zhang, Ming-Gang
Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers
title Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers
title_full Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers
title_fullStr Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers
title_full_unstemmed Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers
title_short Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers
title_sort long non-coding rna signature for liver metastasis of colorectal cancers
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297503/
https://www.ncbi.nlm.nih.gov/pubmed/34307387
http://dx.doi.org/10.3389/fcell.2021.707115
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