Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer

Previous studies have reported that m6a modification promotes tumor immune escape by affecting tumor microenvironment (TME). Due to the complexity of TME, a single biomarker is insufficient to describe the complex biological characteristics of tumor and its microenvironment. Therefore, it is more me...

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Autores principales: Zhou, Yiran, Zhou, Haodong, Shi, Jianlin, Guan, Aoran, Zhu, Yankun, Hou, Zongliu, Li, Ruhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297592/
https://www.ncbi.nlm.nih.gov/pubmed/34307389
http://dx.doi.org/10.3389/fcell.2021.715674
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author Zhou, Yiran
Zhou, Haodong
Shi, Jianlin
Guan, Aoran
Zhu, Yankun
Hou, Zongliu
Li, Ruhong
author_facet Zhou, Yiran
Zhou, Haodong
Shi, Jianlin
Guan, Aoran
Zhu, Yankun
Hou, Zongliu
Li, Ruhong
author_sort Zhou, Yiran
collection PubMed
description Previous studies have reported that m6a modification promotes tumor immune escape by affecting tumor microenvironment (TME). Due to the complexity of TME, a single biomarker is insufficient to describe the complex biological characteristics of tumor and its microenvironment. Therefore, it is more meaningful to explore a group of effective biomarkers reflecting different characteristics of cancer to evaluate the biological characteristics of solid tumors. Here, the immune gene CD34/CD276 with different m6A peak was obtained by m6A sequencing (MeRIP-seq) of colon cancer (CRC)clinical samples and combined with MsIgDB database, which was used to perform cluster analysis on TCGA-COAD level 3 data. The CD34/CD276 as a molecular marker for CRC prognosis was confirmed by survival analysis and immunohistochemical assay. Further bioinformatics analysis was carried out to analyze the molecular mechanism of CD34/CD276 affecting the TME through m6a-dependent down-regulation and ultimately promoting immune escape of CRC.
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spelling pubmed-82975922021-07-23 Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer Zhou, Yiran Zhou, Haodong Shi, Jianlin Guan, Aoran Zhu, Yankun Hou, Zongliu Li, Ruhong Front Cell Dev Biol Cell and Developmental Biology Previous studies have reported that m6a modification promotes tumor immune escape by affecting tumor microenvironment (TME). Due to the complexity of TME, a single biomarker is insufficient to describe the complex biological characteristics of tumor and its microenvironment. Therefore, it is more meaningful to explore a group of effective biomarkers reflecting different characteristics of cancer to evaluate the biological characteristics of solid tumors. Here, the immune gene CD34/CD276 with different m6A peak was obtained by m6A sequencing (MeRIP-seq) of colon cancer (CRC)clinical samples and combined with MsIgDB database, which was used to perform cluster analysis on TCGA-COAD level 3 data. The CD34/CD276 as a molecular marker for CRC prognosis was confirmed by survival analysis and immunohistochemical assay. Further bioinformatics analysis was carried out to analyze the molecular mechanism of CD34/CD276 affecting the TME through m6a-dependent down-regulation and ultimately promoting immune escape of CRC. Frontiers Media S.A. 2021-07-08 /pmc/articles/PMC8297592/ /pubmed/34307389 http://dx.doi.org/10.3389/fcell.2021.715674 Text en Copyright © 2021 Zhou, Zhou, Shi, Guan, Zhu, Hou and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhou, Yiran
Zhou, Haodong
Shi, Jianlin
Guan, Aoran
Zhu, Yankun
Hou, Zongliu
Li, Ruhong
Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer
title Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer
title_full Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer
title_fullStr Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer
title_full_unstemmed Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer
title_short Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer
title_sort decreased m6a modification of cd34/cd276(b7-h3) leads to immune escape in colon cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297592/
https://www.ncbi.nlm.nih.gov/pubmed/34307389
http://dx.doi.org/10.3389/fcell.2021.715674
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