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Mechanistically Guided Design of an Efficient and Enantioselective Aminocatalytic α-Chlorination of Aldehydes

[Image: see text] The enantioselective aminocatalytic α-chlorination of aldehydes is a challenging reaction because of its tendency to proceed through neutral intermediates in unselective pathways. Herein we report the rational shift to a highly selective reaction pathway involving charged intermedi...

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Detalles Bibliográficos
Autores principales:	Hutchinson, George, Alamillo-Ferrer, Carla, Burés, Jordi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297727/ https://www.ncbi.nlm.nih.gov/pubmed/33929823 http://dx.doi.org/10.1021/jacs.1c02997

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