Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF(3)(+), CF(3)(•), and CF(3)(–) Reactivity

[Image: see text] Here we report the synthesis and application of trifluoromethyl thianthrenium triflate (TT-CF(3)(+)OTf(–)) as a novel trifluoromethylating reagent, which is conveniently accessible in a single step from thianthrene and triflic anhydride. We demonstrate the use of TT-CF(3)(+)OTf(–)...

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Detalles Bibliográficos
Autores principales: Jia, Hao, Häring, Andreas P., Berger, Florian, Zhang, Li, Ritter, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297735/
https://www.ncbi.nlm.nih.gov/pubmed/33985330
http://dx.doi.org/10.1021/jacs.1c02606
Descripción
Sumario:[Image: see text] Here we report the synthesis and application of trifluoromethyl thianthrenium triflate (TT-CF(3)(+)OTf(–)) as a novel trifluoromethylating reagent, which is conveniently accessible in a single step from thianthrene and triflic anhydride. We demonstrate the use of TT-CF(3)(+)OTf(–) in electrophilic, radical, and nucleophilic trifluoromethylation reactions.

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