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Computationally efficient model of myocardial electromechanics for multiscale simulations

A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the...

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Autores principales: Syomin, Fyodor, Osepyan, Anna, Tsaturyan, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297763/
https://www.ncbi.nlm.nih.gov/pubmed/34293046
http://dx.doi.org/10.1371/journal.pone.0255027
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author Syomin, Fyodor
Osepyan, Anna
Tsaturyan, Andrey
author_facet Syomin, Fyodor
Osepyan, Anna
Tsaturyan, Andrey
author_sort Syomin, Fyodor
collection PubMed
description A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the propagation velocity of the action potential, are also accounted for. The model reproduces changes in the twitch amplitude and Ca(2+)-transients upon changes in muscle strain including the slow response. The model also reproduces the Bowditch effect and changes in the twitch amplitude and duration upon changes in the interstimulus interval, including accelerated relaxation at high stimulation frequency. Special efforts were taken to reduce the stiffness of the differential equations of the model. As a result, the equations can be integrated numerically with a relatively high time step making the model suitable for multiscale simulation of the human heart and allowing one to study the impact of myocardial mechanics on arrhythmias.
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spelling pubmed-82977632021-07-31 Computationally efficient model of myocardial electromechanics for multiscale simulations Syomin, Fyodor Osepyan, Anna Tsaturyan, Andrey PLoS One Research Article A model of myocardial electromechanics is suggested. It combines modified and simplified versions of previously published models of cardiac electrophysiology, excitation-contraction coupling, and mechanics. The mechano-calcium and mechano-electrical feedbacks, including the strain-dependence of the propagation velocity of the action potential, are also accounted for. The model reproduces changes in the twitch amplitude and Ca(2+)-transients upon changes in muscle strain including the slow response. The model also reproduces the Bowditch effect and changes in the twitch amplitude and duration upon changes in the interstimulus interval, including accelerated relaxation at high stimulation frequency. Special efforts were taken to reduce the stiffness of the differential equations of the model. As a result, the equations can be integrated numerically with a relatively high time step making the model suitable for multiscale simulation of the human heart and allowing one to study the impact of myocardial mechanics on arrhythmias. Public Library of Science 2021-07-22 /pmc/articles/PMC8297763/ /pubmed/34293046 http://dx.doi.org/10.1371/journal.pone.0255027 Text en © 2021 Syomin et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Syomin, Fyodor
Osepyan, Anna
Tsaturyan, Andrey
Computationally efficient model of myocardial electromechanics for multiscale simulations
title Computationally efficient model of myocardial electromechanics for multiscale simulations
title_full Computationally efficient model of myocardial electromechanics for multiscale simulations
title_fullStr Computationally efficient model of myocardial electromechanics for multiscale simulations
title_full_unstemmed Computationally efficient model of myocardial electromechanics for multiscale simulations
title_short Computationally efficient model of myocardial electromechanics for multiscale simulations
title_sort computationally efficient model of myocardial electromechanics for multiscale simulations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297763/
https://www.ncbi.nlm.nih.gov/pubmed/34293046
http://dx.doi.org/10.1371/journal.pone.0255027
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