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A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site

Allosteric integrase inhibitors (ALLINIs) are a class of experimental anti-HIV agents that target the noncatalytic sites of the viral integrase (IN) and interfere with the IN-viral RNA interaction during viral maturation. Here, we report a highly potent and safe pyrrolopyridine-based ALLINI, STP0404...

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Detalles Bibliográficos
Autores principales:	Maehigashi, Tatsuya, Ahn, Seohyun, Kim, Uk-Il, Lindenberger, Jared, Oo, Adrian, Koneru, Pratibha C., Mahboubi, Bijan, Engelman, Alan N., Kvaratskhelia, Mamuka, Kim, Kyungjin, Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297771/ https://www.ncbi.nlm.nih.gov/pubmed/34293041 http://dx.doi.org/10.1371/journal.ppat.1009671

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