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An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis

Sarcopenia is intricately related to aging associated diseases, such as neuropsychiatric disorders, oral status, and chronic diseases. Dementia and depression are interconnected and also related to sarcopenia. The preliminary shift from robust to sarcopenia (i.e., pre-sarcopenia) is an important alb...

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Autores principales: Endo, Takeshi, Akai, Kenju, Kijima, Tsunetaka, Kitahara, Shigetaka, Abe, Takafumi, Takeda, Miwako, Nabika, Toru, Yano, Shozo, Isomura, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297796/
https://www.ncbi.nlm.nih.gov/pubmed/34292967
http://dx.doi.org/10.1371/journal.pone.0252784
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author Endo, Takeshi
Akai, Kenju
Kijima, Tsunetaka
Kitahara, Shigetaka
Abe, Takafumi
Takeda, Miwako
Nabika, Toru
Yano, Shozo
Isomura, Minoru
author_facet Endo, Takeshi
Akai, Kenju
Kijima, Tsunetaka
Kitahara, Shigetaka
Abe, Takafumi
Takeda, Miwako
Nabika, Toru
Yano, Shozo
Isomura, Minoru
author_sort Endo, Takeshi
collection PubMed
description Sarcopenia is intricately related to aging associated diseases, such as neuropsychiatric disorders, oral status, and chronic diseases. Dementia and depression are interconnected and also related to sarcopenia. The preliminary shift from robust to sarcopenia (i.e., pre-sarcopenia) is an important albeit underdiscussed stage and is the focus of this study. Identifying factors associated with pre-sarcopenia may lead to sarcopenia prevention. To separately examine the effects of dementia and depression on pre-sarcopenia/sarcopenia, we conducted multiple analyses. This cross-sectional study used health checkup data from a rural Japanese island. The participants were aged 60 years and above, and the data included muscle mass, gait speed, handgrip strength, oral status (teeth and denture), chronic diseases (e.g., hypertension), dementia (cognitive assessment for dementia, iPad Version), and depression (self-rating depression scale). A total of 753 older adult participants were divided into the sarcopenia (n = 30), pre-sarcopenia (n = 125), and robust (n = 598) groups. An ordered logit regression analysis indicated that age and depression were positively correlated with sarcopenia, while hypertension was negatively associated with it. A multiple logistic regression analysis between the robust and pre-sarcopenia groups showed significant associations between the same three variables. Depression was associated with pre-sarcopenia, but not dementia. There was also a significant association between hypertension and pre-sarcopenia. Further research is needed to reveal whether the management of these factors can prevent sarcopenia.
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spelling pubmed-82977962021-07-31 An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis Endo, Takeshi Akai, Kenju Kijima, Tsunetaka Kitahara, Shigetaka Abe, Takafumi Takeda, Miwako Nabika, Toru Yano, Shozo Isomura, Minoru PLoS One Research Article Sarcopenia is intricately related to aging associated diseases, such as neuropsychiatric disorders, oral status, and chronic diseases. Dementia and depression are interconnected and also related to sarcopenia. The preliminary shift from robust to sarcopenia (i.e., pre-sarcopenia) is an important albeit underdiscussed stage and is the focus of this study. Identifying factors associated with pre-sarcopenia may lead to sarcopenia prevention. To separately examine the effects of dementia and depression on pre-sarcopenia/sarcopenia, we conducted multiple analyses. This cross-sectional study used health checkup data from a rural Japanese island. The participants were aged 60 years and above, and the data included muscle mass, gait speed, handgrip strength, oral status (teeth and denture), chronic diseases (e.g., hypertension), dementia (cognitive assessment for dementia, iPad Version), and depression (self-rating depression scale). A total of 753 older adult participants were divided into the sarcopenia (n = 30), pre-sarcopenia (n = 125), and robust (n = 598) groups. An ordered logit regression analysis indicated that age and depression were positively correlated with sarcopenia, while hypertension was negatively associated with it. A multiple logistic regression analysis between the robust and pre-sarcopenia groups showed significant associations between the same three variables. Depression was associated with pre-sarcopenia, but not dementia. There was also a significant association between hypertension and pre-sarcopenia. Further research is needed to reveal whether the management of these factors can prevent sarcopenia. Public Library of Science 2021-07-22 /pmc/articles/PMC8297796/ /pubmed/34292967 http://dx.doi.org/10.1371/journal.pone.0252784 Text en © 2021 Endo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Endo, Takeshi
Akai, Kenju
Kijima, Tsunetaka
Kitahara, Shigetaka
Abe, Takafumi
Takeda, Miwako
Nabika, Toru
Yano, Shozo
Isomura, Minoru
An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis
title An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis
title_full An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis
title_fullStr An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis
title_full_unstemmed An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis
title_short An association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: A cross-sectional analysis
title_sort association analysis between hypertension, dementia, and depression and the phases of pre-sarcopenia to sarcopenia: a cross-sectional analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297796/
https://www.ncbi.nlm.nih.gov/pubmed/34292967
http://dx.doi.org/10.1371/journal.pone.0252784
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