Cargando…

Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS

BACKGROUND: Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current report describes the pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Dzudie, Anastase, Hoover, Donald, Kim, Hae-Young, Ajeh, Rogers, Adedimeji, Adebola, Shi, Qiuhu, Pefura Yone, Walter, Nsame Nforniwe, Denis, Thompson Njie, Kinge, Pascal Kengne, Andre, Ebasone, Peter Vanes, Barche, Blaise, Bissek Anne Cecile, Zoung-Kany, Nash, Denis, Yotebieng, Marcel, Anastos, Kathryn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297808/
https://www.ncbi.nlm.nih.gov/pubmed/34292956
http://dx.doi.org/10.1371/journal.pone.0253742
_version_ 1783725930930241536
author Dzudie, Anastase
Hoover, Donald
Kim, Hae-Young
Ajeh, Rogers
Adedimeji, Adebola
Shi, Qiuhu
Pefura Yone, Walter
Nsame Nforniwe, Denis
Thompson Njie, Kinge
Pascal Kengne, Andre
Ebasone, Peter Vanes
Barche, Blaise
Bissek Anne Cecile, Zoung-Kany
Nash, Denis
Yotebieng, Marcel
Anastos, Kathryn
author_facet Dzudie, Anastase
Hoover, Donald
Kim, Hae-Young
Ajeh, Rogers
Adedimeji, Adebola
Shi, Qiuhu
Pefura Yone, Walter
Nsame Nforniwe, Denis
Thompson Njie, Kinge
Pascal Kengne, Andre
Ebasone, Peter Vanes
Barche, Blaise
Bissek Anne Cecile, Zoung-Kany
Nash, Denis
Yotebieng, Marcel
Anastos, Kathryn
author_sort Dzudie, Anastase
collection PubMed
description BACKGROUND: Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current report describes the prevalence and predictors of HTN among PLWH in care in Cameroon. METHODS: This cross-sectional study included all PLWH aged 20 years and above who received care between 2016 and 2019 at one of the three Central Africa International Epidemiology Databases to Evaluate AIDS (CA-IeDEA) sites in Cameroon (Bamenda, Limbe, and Yaoundé). HTN was defined as blood pressure (BP) ≥140/90 mm Hg or self-reported use of antihypertensive medication. Logistic regressions models examined the relationship between HTN and clinical characteristics, and HIV-related factors. RESULTS: Among 9,839 eligible PLWH, 66.2% were women and 25.0% had prevalent HTN [age-standardized prevalence 23.9% (95% CI: 22.2–25.6)], among whom 28 (1.1%) were on BP lowering treatment, and 6 of those (21.4%) were at target BP levels. Median age (47.4 vs. 40.5 years), self-reported duration of HIV infection (5.1 vs 2.8 years years), duration of ART exposure (4.7 vs 2.3 years), and CD4 count (408 vs 359 cell/mm(3)) were higher in hypertensives than non-hypertensives (all p<0.001). Age and body mass index (BMI) were independently associated with higher prevalent HTN risk. PLWH starting ART had a 30% lower risk of prevalent HTN, but this advantage disappeared after a cumulative 2-year exposure to ART. There was no significant association between other HIV predictive characteristics and HTN. CONCLUSION: About a quarter of these Cameroonian PLWH had HTN, driven among others by age and adiposity. Appropriate integration of HIV and NCDs services is needed to improve early detection, treatment and control of common comorbid NCD risk factors like hypertension and safeguard cardiovascular health in PLWH.
format Online
Article
Text
id pubmed-8297808
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-82978082021-07-31 Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS Dzudie, Anastase Hoover, Donald Kim, Hae-Young Ajeh, Rogers Adedimeji, Adebola Shi, Qiuhu Pefura Yone, Walter Nsame Nforniwe, Denis Thompson Njie, Kinge Pascal Kengne, Andre Ebasone, Peter Vanes Barche, Blaise Bissek Anne Cecile, Zoung-Kany Nash, Denis Yotebieng, Marcel Anastos, Kathryn PLoS One Research Article BACKGROUND: Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current report describes the prevalence and predictors of HTN among PLWH in care in Cameroon. METHODS: This cross-sectional study included all PLWH aged 20 years and above who received care between 2016 and 2019 at one of the three Central Africa International Epidemiology Databases to Evaluate AIDS (CA-IeDEA) sites in Cameroon (Bamenda, Limbe, and Yaoundé). HTN was defined as blood pressure (BP) ≥140/90 mm Hg or self-reported use of antihypertensive medication. Logistic regressions models examined the relationship between HTN and clinical characteristics, and HIV-related factors. RESULTS: Among 9,839 eligible PLWH, 66.2% were women and 25.0% had prevalent HTN [age-standardized prevalence 23.9% (95% CI: 22.2–25.6)], among whom 28 (1.1%) were on BP lowering treatment, and 6 of those (21.4%) were at target BP levels. Median age (47.4 vs. 40.5 years), self-reported duration of HIV infection (5.1 vs 2.8 years years), duration of ART exposure (4.7 vs 2.3 years), and CD4 count (408 vs 359 cell/mm(3)) were higher in hypertensives than non-hypertensives (all p<0.001). Age and body mass index (BMI) were independently associated with higher prevalent HTN risk. PLWH starting ART had a 30% lower risk of prevalent HTN, but this advantage disappeared after a cumulative 2-year exposure to ART. There was no significant association between other HIV predictive characteristics and HTN. CONCLUSION: About a quarter of these Cameroonian PLWH had HTN, driven among others by age and adiposity. Appropriate integration of HIV and NCDs services is needed to improve early detection, treatment and control of common comorbid NCD risk factors like hypertension and safeguard cardiovascular health in PLWH. Public Library of Science 2021-07-22 /pmc/articles/PMC8297808/ /pubmed/34292956 http://dx.doi.org/10.1371/journal.pone.0253742 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Dzudie, Anastase
Hoover, Donald
Kim, Hae-Young
Ajeh, Rogers
Adedimeji, Adebola
Shi, Qiuhu
Pefura Yone, Walter
Nsame Nforniwe, Denis
Thompson Njie, Kinge
Pascal Kengne, Andre
Ebasone, Peter Vanes
Barche, Blaise
Bissek Anne Cecile, Zoung-Kany
Nash, Denis
Yotebieng, Marcel
Anastos, Kathryn
Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS
title Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS
title_full Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS
title_fullStr Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS
title_full_unstemmed Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS
title_short Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS
title_sort hypertension among people living with hiv/aids in cameroon: a cross-sectional analysis from central africa international epidemiology databases to evaluate aids
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297808/
https://www.ncbi.nlm.nih.gov/pubmed/34292956
http://dx.doi.org/10.1371/journal.pone.0253742
work_keys_str_mv AT dzudieanastase hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT hooverdonald hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT kimhaeyoung hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT ajehrogers hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT adedimejiadebola hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT shiqiuhu hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT pefurayonewalter hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT nsamenforniwedenis hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT thompsonnjiekinge hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT pascalkengneandre hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT ebasonepetervanes hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT barcheblaise hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT bissekannececilezoungkany hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT nashdenis hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT yotebiengmarcel hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids
AT anastoskathryn hypertensionamongpeoplelivingwithhivaidsincameroonacrosssectionalanalysisfromcentralafricainternationalepidemiologydatabasestoevaluateaids