Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors

Many viruses utilize the host endo-lysosomal network for infection. Tracing the endocytic itinerary of SARS-CoV-2 can provide insights into viral trafficking and aid in designing new therapeutic strategies. Here, we demonstrate that the receptor binding domain (RBD) of SARS-CoV-2 spike protein is in...

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Detalles Bibliográficos
Autores principales: Prabhakara, Chaitra, Godbole, Rashmi, Sil, Parijat, Jahnavi, Sowmya, Gulzar, Shah-e-Jahan, van Zanten, Thomas S., Sheth, Dhruv, Subhash, Neeraja, Chandra, Anchal, Shivaraj, Akshatha, Panikulam, Patricia, U, Ibrahim, Nuthakki, Vijay Kumar, Puthiyapurayil, Theja Parassini, Ahmed, Riyaz, Najar, Ashaq Hussain, Lingamallu, Sai Manoz, Das, Snigdhadev, Mahajan, Bhagyashri, Vemula, Praveen, Bharate, Sandip B., Singh, Parvinder Pal, Vishwakarma, Ram, Guha, Arjun, Sundaramurthy, Varadharajan, Mayor, Satyajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297935/
https://www.ncbi.nlm.nih.gov/pubmed/34252168
http://dx.doi.org/10.1371/journal.ppat.1009706

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