Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease

Many skin manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection reflect activation of cutaneous and systemic immune responses involving effector pathways of both the innate and adaptive arms of the immune system. This article reviews evidence from the recent clinic...

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Detalles Bibliográficos
Autores principales: Gallman, Antonia E., Fassett, Marlys S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297957/
https://www.ncbi.nlm.nih.gov/pubmed/34556243
http://dx.doi.org/10.1016/j.det.2021.05.008
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author Gallman, Antonia E.
Fassett, Marlys S.
author_facet Gallman, Antonia E.
Fassett, Marlys S.
author_sort Gallman, Antonia E.
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description Many skin manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection reflect activation of cutaneous and systemic immune responses involving effector pathways of both the innate and adaptive arms of the immune system. This article reviews evidence from the recent clinical and scientific literature that informs the current understanding of the consequences of coronavirus disease 2019 (COVID-19)–induced immune cell activation, as relevant to dermatology. Topics include the clinical consequences of autoantibody production in patients with COVID-19, immunologic evidence for chilblains as a manifestation of SARS-CoV-2 infection, and the relationship between type I interferons and COVID-19 disease severity.
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spelling pubmed-82979572021-07-23 Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease Gallman, Antonia E. Fassett, Marlys S. Dermatol Clin Article Many skin manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection reflect activation of cutaneous and systemic immune responses involving effector pathways of both the innate and adaptive arms of the immune system. This article reviews evidence from the recent clinical and scientific literature that informs the current understanding of the consequences of coronavirus disease 2019 (COVID-19)–induced immune cell activation, as relevant to dermatology. Topics include the clinical consequences of autoantibody production in patients with COVID-19, immunologic evidence for chilblains as a manifestation of SARS-CoV-2 infection, and the relationship between type I interferons and COVID-19 disease severity. Elsevier Inc. 2021-10 2021-07-22 /pmc/articles/PMC8297957/ /pubmed/34556243 http://dx.doi.org/10.1016/j.det.2021.05.008 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gallman, Antonia E.
Fassett, Marlys S.
Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease
title Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease
title_full Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease
title_fullStr Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease
title_full_unstemmed Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease
title_short Cutaneous Pathology of COVID-19 as a Window into Immunologic Mechanisms of Disease
title_sort cutaneous pathology of covid-19 as a window into immunologic mechanisms of disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297957/
https://www.ncbi.nlm.nih.gov/pubmed/34556243
http://dx.doi.org/10.1016/j.det.2021.05.008
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