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An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran

BACKGROUND & OBJECTIVE: Pancreatobiliary system disorders commonly include inflammatory diseases and tumors. Diagnosis of pancreatic cancer is challenging and is mostly achieved when the disease has extensively progressed, and metastasis has occurred. Therefore, this study was performed to evalu...

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Autores principales: Moradi, Afshin, Sadeghi, Amir, Asadzadeh Aghdaei, Hamid, Mollasharifi, Tahmineh, Ahadi, Mahsa, Jamali, Elena, Taghavi, Afsoon, Foroozandeh Shahraki, Nasim, Moradi, Arsham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298047/
https://www.ncbi.nlm.nih.gov/pubmed/34306121
http://dx.doi.org/10.30699/IJP.2021.131467.2462
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author Moradi, Afshin
Sadeghi, Amir
Asadzadeh Aghdaei, Hamid
Mollasharifi, Tahmineh
Ahadi, Mahsa
Jamali, Elena
Taghavi, Afsoon
Foroozandeh Shahraki, Nasim
Moradi, Arsham
author_facet Moradi, Afshin
Sadeghi, Amir
Asadzadeh Aghdaei, Hamid
Mollasharifi, Tahmineh
Ahadi, Mahsa
Jamali, Elena
Taghavi, Afsoon
Foroozandeh Shahraki, Nasim
Moradi, Arsham
author_sort Moradi, Afshin
collection PubMed
description BACKGROUND & OBJECTIVE: Pancreatobiliary system disorders commonly include inflammatory diseases and tumors. Diagnosis of pancreatic cancer is challenging and is mostly achieved when the disease has extensively progressed, and metastasis has occurred. Therefore, this study was performed to evaluate cytopathology in the diagnosis of Pancreatobiliary malignancies, which can improve diagnostic adequacy and accuracy. METHODS: A total of 116 cytopathologic results of the Pancreatobiliary system, performed in the Pathology Department of Taleghani Hospital, Tehran, Iran during 2017-2018 were selected and examined in this observational study. The frequency of different results was determined and compared with other variables. RESULTS: The most common location of the lesions was the pancreas (47%). The lesions were categorized as malignant, benign, negative, suspicious for malignancy (SFM), and atypical in 28%, 10%, 24%, 14%, and 9% of the cases, respectively. In other cases, lesions were considered non-diagnostic. Rapid on-site evaluation (ROSE) was conducted in 25% of patients. Compatibility of the initial and final diagnoses was 100%, 50%, and 60% in cases with “malignant”, “benign”, and “negative” diagnoses, respectively. The sensitivity, specificity, as well as positive and negative predictive values of cytopathology in the diagnosis of Pancreatobiliary lesions were 75.8%, 92.3%, 95.9%, and 61.5%, respectively. CONCLUSION: Our findings indicated that half of the lesions of the Pancreatobiliary system were positive, SFM, and atypical. Fine-needle aspiration (FNA) and endoscopic ultrasound-guided FNA (EUS-FNA) were effective modalities in diagnosing Pancreatobiliary malignancies. The most important point in our experience is the increase in diagnostic sensitivity in the presence of ROSE. Therefore, the simultaneous use of ROSE and EUS-FNA can reduce the need for re-sampling.
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spelling pubmed-82980472021-07-23 An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran Moradi, Afshin Sadeghi, Amir Asadzadeh Aghdaei, Hamid Mollasharifi, Tahmineh Ahadi, Mahsa Jamali, Elena Taghavi, Afsoon Foroozandeh Shahraki, Nasim Moradi, Arsham Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Pancreatobiliary system disorders commonly include inflammatory diseases and tumors. Diagnosis of pancreatic cancer is challenging and is mostly achieved when the disease has extensively progressed, and metastasis has occurred. Therefore, this study was performed to evaluate cytopathology in the diagnosis of Pancreatobiliary malignancies, which can improve diagnostic adequacy and accuracy. METHODS: A total of 116 cytopathologic results of the Pancreatobiliary system, performed in the Pathology Department of Taleghani Hospital, Tehran, Iran during 2017-2018 were selected and examined in this observational study. The frequency of different results was determined and compared with other variables. RESULTS: The most common location of the lesions was the pancreas (47%). The lesions were categorized as malignant, benign, negative, suspicious for malignancy (SFM), and atypical in 28%, 10%, 24%, 14%, and 9% of the cases, respectively. In other cases, lesions were considered non-diagnostic. Rapid on-site evaluation (ROSE) was conducted in 25% of patients. Compatibility of the initial and final diagnoses was 100%, 50%, and 60% in cases with “malignant”, “benign”, and “negative” diagnoses, respectively. The sensitivity, specificity, as well as positive and negative predictive values of cytopathology in the diagnosis of Pancreatobiliary lesions were 75.8%, 92.3%, 95.9%, and 61.5%, respectively. CONCLUSION: Our findings indicated that half of the lesions of the Pancreatobiliary system were positive, SFM, and atypical. Fine-needle aspiration (FNA) and endoscopic ultrasound-guided FNA (EUS-FNA) were effective modalities in diagnosing Pancreatobiliary malignancies. The most important point in our experience is the increase in diagnostic sensitivity in the presence of ROSE. Therefore, the simultaneous use of ROSE and EUS-FNA can reduce the need for re-sampling. Iranian Society of Pathology 2021 2021-05-05 /pmc/articles/PMC8298047/ /pubmed/34306121 http://dx.doi.org/10.30699/IJP.2021.131467.2462 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Moradi, Afshin
Sadeghi, Amir
Asadzadeh Aghdaei, Hamid
Mollasharifi, Tahmineh
Ahadi, Mahsa
Jamali, Elena
Taghavi, Afsoon
Foroozandeh Shahraki, Nasim
Moradi, Arsham
An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran
title An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran
title_full An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran
title_fullStr An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran
title_full_unstemmed An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran
title_short An Investigation on the Results of Cytopathologic Tests of Pancreatobiliary System Performed in the Pathology Department in Iran
title_sort investigation on the results of cytopathologic tests of pancreatobiliary system performed in the pathology department in iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298047/
https://www.ncbi.nlm.nih.gov/pubmed/34306121
http://dx.doi.org/10.30699/IJP.2021.131467.2462
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