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PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs

The tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) have been widely used for non-small cell lung cancer (NSCLC) patients, but the development of acquired resistance remains a therapeutic hurdle. The reduction of glucose uptake has been implicated in the anti-tumo...

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Detalles Bibliográficos
Autores principales:	Chen, Chia-Hung, Wang, Bo-Wei, Hsiao, Yu-Chun, Wu, Chun-Yi, Cheng, Fang-Ju, Hsia, Te-Chun, Chen, Chih-Yi, Wang, Yihua, Weihua, Zhang, Chou, Ruey-Hwang, Tang, Chih-Hsin, Chen, Yun-Ju, Wei, Ya-Ling, Hsu, Jennifer L., Tu, Chih-Yen, Hung, Mien-Chie, Huang, Wei-Chien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298203/ https://www.ncbi.nlm.nih.gov/pubmed/34155348 http://dx.doi.org/10.1038/s41388-021-01889-0

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