Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these antibiotics are known to interrupt translation at specific sequence motifs, with ketolides predominantly stalling at...

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Detalles Bibliográficos
Autores principales: Beckert, Bertrand, Leroy, Elodie C., Sothiselvam, Shanmugapriya, Bock, Lars V., Svetlov, Maxim S., Graf, Michael, Arenz, Stefan, Abdelshahid, Maha, Seip, Britta, Grubmüller, Helmut, Mankin, Alexander S., Innis, C. Axel, Vázquez-Laslop, Nora, Wilson, Daniel N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298421/
https://www.ncbi.nlm.nih.gov/pubmed/34294725
http://dx.doi.org/10.1038/s41467-021-24674-9

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