Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation

Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. Here, we demonstrate that the human tumor-derived NKG2D ligand soluble MIC (sMIC) reprograms NK cell to secrete pro...

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Detalles Bibliográficos
Autores principales: Dhar, Payal, Basher, Fahmin, Ji, Zhe, Huang, Lei, Qin, Si, Wainwright, Derek A., Robinson, Jerid, Hagler, Shaye, Zhou, Jing, MacKay, Sean, Wu, Jennifer D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298432/
https://www.ncbi.nlm.nih.gov/pubmed/34294876
http://dx.doi.org/10.1038/s42003-021-02440-3

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