Cargando…
Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays
Family and population studies indicate clear heritability of major depressive disorder (MDD), though its underlying biology remains unclear. The majority of single-nucleotide polymorphism (SNP) linkage blocks associated with MDD by genome-wide association studies (GWASes) are believed to alter trans...
Autores principales: | Mulvey, Bernard, Dougherty, Joseph D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298436/ https://www.ncbi.nlm.nih.gov/pubmed/34294677 http://dx.doi.org/10.1038/s41398-021-01493-6 |
Ejemplares similares
-
A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells
por: Maricque, Brett B., et al.
Publicado: (2017) -
High-throughput functional analysis of regulatory variants using a massively parallel reporter assay
por: Delfosse, Kate, et al.
Publicado: (2023) -
Meta‐analysis of massively parallel reporter assays enables prediction of regulatory function across cell types
por: Kreimer, Anat, et al.
Publicado: (2019) -
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
por: Choi, Jiyeon, et al.
Publicado: (2020) -
Deciphering regulatory DNA sequences and noncoding genetic variants using neural network models of massively parallel reporter assays
por: Movva, Rajiv, et al.
Publicado: (2019)