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BCG therapy is associated with long-term, durable induction of Treg signature genes by epigenetic modulation
Induction of immunosuppressive T-regulatory cells (Tregs) is a desirable goal in autoimmunity, and perhaps other immune diseases of activation. One promising avenue is with the bacille-calmette-guérin (BCG) vaccine in autoimmune type 1 diabetes (T1D). Its administration is associated with gradual cl...
Autores principales: | Keefe, Ryan C., Takahashi, Hiroyuki, Tran, Lisa, Nelson, Kacie, Ng, Nathan, Kühtreiber, Willem M., Faustman, Denise L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298580/ https://www.ncbi.nlm.nih.gov/pubmed/34294806 http://dx.doi.org/10.1038/s41598-021-94529-2 |
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