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14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

Neural precursor cell expressed developmentally down-regulated 4 ligase (Nedd4-2) is an E3 ubiquitin ligase that targets proteins for ubiquitination and endocytosis, thereby regulating numerous ion channels, membrane receptors and tumor suppressors. Nedd4-2 activity is regulated by autoinhibition, c...

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Detalles Bibliográficos
Autores principales:	Pohl, Pavel, Joshi, Rohit, Petrvalska, Olivia, Obsil, Tomas, Obsilova, Veronika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298602/ https://www.ncbi.nlm.nih.gov/pubmed/34294877 http://dx.doi.org/10.1038/s42003-021-02419-0

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