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The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease
BACKGROUND: Interstitial lung disease (ILD) and its rapid progression (RP) are the main contributors to unfavourable outcomes of patients with idiopathic inflammatory myopathy (IIM). This study aimed to identify the clinical value of PET/CT scans in IIM-ILD patients and to construct a predictive mod...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298695/ https://www.ncbi.nlm.nih.gov/pubmed/34301306 http://dx.doi.org/10.1186/s13075-021-02578-9 |
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author | Liang, Junyu Cao, Heng Liu, Yinuo Ye, Bingjue Sun, Yiduo Ke, Yini He, Ye Xu, Bei Lin, Jin |
author_facet | Liang, Junyu Cao, Heng Liu, Yinuo Ye, Bingjue Sun, Yiduo Ke, Yini He, Ye Xu, Bei Lin, Jin |
author_sort | Liang, Junyu |
collection | PubMed |
description | BACKGROUND: Interstitial lung disease (ILD) and its rapid progression (RP) are the main contributors to unfavourable outcomes of patients with idiopathic inflammatory myopathy (IIM). This study aimed to identify the clinical value of PET/CT scans in IIM-ILD patients and to construct a predictive model for RP-ILD. METHODS: Adult IIM-ILD patients who were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZJU), from 1 January 2017 to 31 December 2020 were reviewed. PET/CT scans and other characteristics of patients who met the inclusion and exclusion criteria were collected and analysed. RESULTS: A total of 61 IIM-ILD patients were enrolled in this study. Twenty-one patients (34.4%) developed RP-ILD, and 24 patients (39.3%) died during follow-up. After false discovery rate (FDR) correction, the percent-predicted diffusing capacity of the lung for carbon monoxide (DLCO%, P = 0.014), bilateral lung mean standard uptake value (SUVmean, P = 0.014) and abnormal mediastinal lymph node (P = 0.045) were significantly different between the RP-ILD and non-RP-ILD groups. The subsequent univariate and multivariate logistic regression analyses verified our findings. A “DLM” model was established by including the above three values to predict RP-ILD with a cut-off value of ≥ 2 and an area under the curve (AUC) of 0.905. Higher bilateral lung SUVmean (P = 0.019) and spleen SUVmean (P = 0.011) were observed in IIM-ILD patients who died within 3 months, and a moderate correlation was recognized between the two values. CONCLUSIONS: Elevated bilateral lung SUVmean, abnormal mediastinal lymph nodes and decreased DLCO% were significantly associated with RP-ILD in IIM-ILD patients. The “DLM” model was valuable in predicting RP-ILD and requires further validation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-021-02578-9. |
format | Online Article Text |
id | pubmed-8298695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82986952021-07-23 The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease Liang, Junyu Cao, Heng Liu, Yinuo Ye, Bingjue Sun, Yiduo Ke, Yini He, Ye Xu, Bei Lin, Jin Arthritis Res Ther Research Article BACKGROUND: Interstitial lung disease (ILD) and its rapid progression (RP) are the main contributors to unfavourable outcomes of patients with idiopathic inflammatory myopathy (IIM). This study aimed to identify the clinical value of PET/CT scans in IIM-ILD patients and to construct a predictive model for RP-ILD. METHODS: Adult IIM-ILD patients who were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZJU), from 1 January 2017 to 31 December 2020 were reviewed. PET/CT scans and other characteristics of patients who met the inclusion and exclusion criteria were collected and analysed. RESULTS: A total of 61 IIM-ILD patients were enrolled in this study. Twenty-one patients (34.4%) developed RP-ILD, and 24 patients (39.3%) died during follow-up. After false discovery rate (FDR) correction, the percent-predicted diffusing capacity of the lung for carbon monoxide (DLCO%, P = 0.014), bilateral lung mean standard uptake value (SUVmean, P = 0.014) and abnormal mediastinal lymph node (P = 0.045) were significantly different between the RP-ILD and non-RP-ILD groups. The subsequent univariate and multivariate logistic regression analyses verified our findings. A “DLM” model was established by including the above three values to predict RP-ILD with a cut-off value of ≥ 2 and an area under the curve (AUC) of 0.905. Higher bilateral lung SUVmean (P = 0.019) and spleen SUVmean (P = 0.011) were observed in IIM-ILD patients who died within 3 months, and a moderate correlation was recognized between the two values. CONCLUSIONS: Elevated bilateral lung SUVmean, abnormal mediastinal lymph nodes and decreased DLCO% were significantly associated with RP-ILD in IIM-ILD patients. The “DLM” model was valuable in predicting RP-ILD and requires further validation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-021-02578-9. BioMed Central 2021-07-23 2021 /pmc/articles/PMC8298695/ /pubmed/34301306 http://dx.doi.org/10.1186/s13075-021-02578-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Liang, Junyu Cao, Heng Liu, Yinuo Ye, Bingjue Sun, Yiduo Ke, Yini He, Ye Xu, Bei Lin, Jin The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease |
title | The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease |
title_full | The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease |
title_fullStr | The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease |
title_full_unstemmed | The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease |
title_short | The lungs were on fire: a pilot study of (18)F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease |
title_sort | lungs were on fire: a pilot study of (18)f-fdg pet/ct in idiopathic-inflammatory-myopathy-related interstitial lung disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298695/ https://www.ncbi.nlm.nih.gov/pubmed/34301306 http://dx.doi.org/10.1186/s13075-021-02578-9 |
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