Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years

Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory myocarditis confirmed by electron microscopy. Tacrolimus and mycophenolate transiently reduced inflammation, but antithymocyte globulin induced remissi...

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Detalles Bibliográficos
Autores principales: Norwood, Timothy G., Lenneman, Carrie A., Westbrook, Brian C., Litovsky, Silvio H., McKee, Svetlana B., Conry, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Mini-Focus Issue: Myocardial and Pericardial Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298699/
https://www.ncbi.nlm.nih.gov/pubmed/34317205
http://dx.doi.org/10.1016/j.jaccas.2019.11.076
Descripción
Sumario:Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory myocarditis confirmed by electron microscopy. Tacrolimus and mycophenolate transiently reduced inflammation, but antithymocyte globulin induced remission. Cardiomyopathy with fatty infiltration ensued, but the patient succumbed to rampant melanoma progression after lymphocyte depletion. (Level of Difficulty: Advanced.)

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