Cargando…
Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years
Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory myocarditis confirmed by electron microscopy. Tacrolimus and mycophenolate transiently reduced inflammation, but antithymocyte globulin induced remissi...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298699/ https://www.ncbi.nlm.nih.gov/pubmed/34317205 http://dx.doi.org/10.1016/j.jaccas.2019.11.076 |
| _version_ | 1783726113155973120 |
|---|---|
| author | Norwood, Timothy G. Lenneman, Carrie A. Westbrook, Brian C. Litovsky, Silvio H. McKee, Svetlana B. Conry, Robert M. |
| author_facet | Norwood, Timothy G. Lenneman, Carrie A. Westbrook, Brian C. Litovsky, Silvio H. McKee, Svetlana B. Conry, Robert M. |
| author_sort | Norwood, Timothy G. |
| collection | PubMed |
| description | Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory myocarditis confirmed by electron microscopy. Tacrolimus and mycophenolate transiently reduced inflammation, but antithymocyte globulin induced remission. Cardiomyopathy with fatty infiltration ensued, but the patient succumbed to rampant melanoma progression after lymphocyte depletion. (Level of Difficulty: Advanced.) |
| format | Online Article Text |
| id | pubmed-8298699 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82986992021-07-26 Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years Norwood, Timothy G. Lenneman, Carrie A. Westbrook, Brian C. Litovsky, Silvio H. McKee, Svetlana B. Conry, Robert M. JACC Case Rep Mini-Focus Issue: Myocardial and Pericardial Inflammation Ipilimumab and nivolumab for melanoma induced smoldering myocarditis remitting with steroids. Rechallenge with nivolumab produced steroid-refractory myocarditis confirmed by electron microscopy. Tacrolimus and mycophenolate transiently reduced inflammation, but antithymocyte globulin induced remission. Cardiomyopathy with fatty infiltration ensued, but the patient succumbed to rampant melanoma progression after lymphocyte depletion. (Level of Difficulty: Advanced.) Elsevier 2020-02-19 /pmc/articles/PMC8298699/ /pubmed/34317205 http://dx.doi.org/10.1016/j.jaccas.2019.11.076 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Mini-Focus Issue: Myocardial and Pericardial Inflammation Norwood, Timothy G. Lenneman, Carrie A. Westbrook, Brian C. Litovsky, Silvio H. McKee, Svetlana B. Conry, Robert M. Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years |
| title | Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years |
| title_full | Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years |
| title_fullStr | Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years |
| title_full_unstemmed | Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years |
| title_short | Evolution of Immune Checkpoint Blockade–Induced Myocarditis Over 2 Years |
| title_sort | evolution of immune checkpoint blockade–induced myocarditis over 2 years |
| topic | Mini-Focus Issue: Myocardial and Pericardial Inflammation |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298699/ https://www.ncbi.nlm.nih.gov/pubmed/34317205 http://dx.doi.org/10.1016/j.jaccas.2019.11.076 |
| work_keys_str_mv | AT norwoodtimothyg evolutionofimmunecheckpointblockadeinducedmyocarditisover2years AT lennemancarriea evolutionofimmunecheckpointblockadeinducedmyocarditisover2years AT westbrookbrianc evolutionofimmunecheckpointblockadeinducedmyocarditisover2years AT litovskysilvioh evolutionofimmunecheckpointblockadeinducedmyocarditisover2years AT mckeesvetlanab evolutionofimmunecheckpointblockadeinducedmyocarditisover2years AT conryrobertm evolutionofimmunecheckpointblockadeinducedmyocarditisover2years |