Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation

More than 30 patients with multiple sclerosis (MS) and Parkinson's disease (PD) have been reported so far. Theories on the co-occurrence of MS and PD range from coincidental to causal. There has been only one report of MS in young onset PD in a patient heterozygous for Parkin mutation. We repor...

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Detalles Bibliográficos
Autores principales: Delalić, Sentilija, Rus, Tomaž, Horvat Ledinek, Alenka, Kojović, Maja, Georgiev, Dejan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Correspondence (including Letter to the Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298765/
https://www.ncbi.nlm.nih.gov/pubmed/34316638
http://dx.doi.org/10.1016/j.prdoa.2020.100055
Descripción
Sumario:More than 30 patients with multiple sclerosis (MS) and Parkinson's disease (PD) have been reported so far. Theories on the co-occurrence of MS and PD range from coincidental to causal. There has been only one report of MS in young onset PD in a patient heterozygous for Parkin mutation. We report a patient with MS who developed signs typical for PD and was found to be heterozygous mutation carrier in the gene for glucocerebrosidase (GBA1), a well-known risk factor for PD.

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