Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation

More than 30 patients with multiple sclerosis (MS) and Parkinson's disease (PD) have been reported so far. Theories on the co-occurrence of MS and PD range from coincidental to causal. There has been only one report of MS in young onset PD in a patient heterozygous for Parkin mutation. We repor...

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Autores principales: Delalić, Sentilija, Rus, Tomaž, Horvat Ledinek, Alenka, Kojović, Maja, Georgiev, Dejan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Correspondence (including Letter to the Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298765/
https://www.ncbi.nlm.nih.gov/pubmed/34316638
http://dx.doi.org/10.1016/j.prdoa.2020.100055
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author Delalić, Sentilija
Rus, Tomaž
Horvat Ledinek, Alenka
Kojović, Maja
Georgiev, Dejan
author_facet Delalić, Sentilija
Rus, Tomaž
Horvat Ledinek, Alenka
Kojović, Maja
Georgiev, Dejan
author_sort Delalić, Sentilija
collection PubMed
description More than 30 patients with multiple sclerosis (MS) and Parkinson's disease (PD) have been reported so far. Theories on the co-occurrence of MS and PD range from coincidental to causal. There has been only one report of MS in young onset PD in a patient heterozygous for Parkin mutation. We report a patient with MS who developed signs typical for PD and was found to be heterozygous mutation carrier in the gene for glucocerebrosidase (GBA1), a well-known risk factor for PD.
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spelling pubmed-82987652021-07-26 Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation Delalić, Sentilija Rus, Tomaž Horvat Ledinek, Alenka Kojović, Maja Georgiev, Dejan Clin Park Relat Disord Correspondence (including Letter to the Editor) More than 30 patients with multiple sclerosis (MS) and Parkinson's disease (PD) have been reported so far. Theories on the co-occurrence of MS and PD range from coincidental to causal. There has been only one report of MS in young onset PD in a patient heterozygous for Parkin mutation. We report a patient with MS who developed signs typical for PD and was found to be heterozygous mutation carrier in the gene for glucocerebrosidase (GBA1), a well-known risk factor for PD. Elsevier 2020-04-30 /pmc/articles/PMC8298765/ /pubmed/34316638 http://dx.doi.org/10.1016/j.prdoa.2020.100055 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Correspondence (including Letter to the Editor)
Delalić, Sentilija
Rus, Tomaž
Horvat Ledinek, Alenka
Kojović, Maja
Georgiev, Dejan
Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation
title Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation
title_full Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation
title_fullStr Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation
title_full_unstemmed Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation
title_short Parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation
title_sort parkinson's disease in a patient with multiple sclerosis and heterozygous glucocerebrosidase gene mutation
topic Correspondence (including Letter to the Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298765/
https://www.ncbi.nlm.nih.gov/pubmed/34316638
http://dx.doi.org/10.1016/j.prdoa.2020.100055
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