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Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence
Parkinsonism related to chronic Manganese exposure is notably due to focal lesions of the basal ganglia. Our study focused on epidemiological, clinical, toxicological and experimental aspects of Manganese-induced Parkinsonism in south of Morocco. It is a prospective study concerning the workers and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298767/ https://www.ncbi.nlm.nih.gov/pubmed/34316640 http://dx.doi.org/10.1016/j.prdoa.2020.100057 |
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author | Kissani, Najib Naji, Yahya Mebrouk, Yassine Chraa, Mohamed Ghanima, Abderrazzak |
author_facet | Kissani, Najib Naji, Yahya Mebrouk, Yassine Chraa, Mohamed Ghanima, Abderrazzak |
author_sort | Kissani, Najib |
collection | PubMed |
description | Parkinsonism related to chronic Manganese exposure is notably due to focal lesions of the basal ganglia. Our study focused on epidemiological, clinical, toxicological and experimental aspects of Manganese-induced Parkinsonism in south of Morocco. It is a prospective study concerning the workers and the residents bordering on the 2 mines in the south of Morocco. The results of the study concerned 120 cases divided into 4 groups of patients: G1: 30 cases exposed to different incriminated toxic products, which present Parkinsonian signs, G2: 30 cases healthy and exposed, G3: 30 cases affected with Idiopathic Parkinson's disease, and G4: 30 cases healthy and unexposed (controls). The results from the first mine show that 5.7% of the sample developed Manganese-Induced Parkinsonism and this percentage is slightly higher (4.5%) than the second mine site. Chemical and biological analysis revealed high levels of Manganese. The majority of patients did not improve the clinical signs under L-dopa treatment. The authors underline the gravity of Manganese-induced Parkinsonism and propose a listing of the various exposures as well as a cartography of the regions of risk in Morocco. |
format | Online Article Text |
id | pubmed-8298767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82987672021-07-26 Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence Kissani, Najib Naji, Yahya Mebrouk, Yassine Chraa, Mohamed Ghanima, Abderrazzak Clin Park Relat Disord Original Article Parkinsonism related to chronic Manganese exposure is notably due to focal lesions of the basal ganglia. Our study focused on epidemiological, clinical, toxicological and experimental aspects of Manganese-induced Parkinsonism in south of Morocco. It is a prospective study concerning the workers and the residents bordering on the 2 mines in the south of Morocco. The results of the study concerned 120 cases divided into 4 groups of patients: G1: 30 cases exposed to different incriminated toxic products, which present Parkinsonian signs, G2: 30 cases healthy and exposed, G3: 30 cases affected with Idiopathic Parkinson's disease, and G4: 30 cases healthy and unexposed (controls). The results from the first mine show that 5.7% of the sample developed Manganese-Induced Parkinsonism and this percentage is slightly higher (4.5%) than the second mine site. Chemical and biological analysis revealed high levels of Manganese. The majority of patients did not improve the clinical signs under L-dopa treatment. The authors underline the gravity of Manganese-induced Parkinsonism and propose a listing of the various exposures as well as a cartography of the regions of risk in Morocco. Elsevier 2020-05-06 /pmc/articles/PMC8298767/ /pubmed/34316640 http://dx.doi.org/10.1016/j.prdoa.2020.100057 Text en © 2020 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Kissani, Najib Naji, Yahya Mebrouk, Yassine Chraa, Mohamed Ghanima, Abderrazzak Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence |
title | Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence |
title_full | Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence |
title_fullStr | Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence |
title_full_unstemmed | Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence |
title_short | Parkinsonism and chronic manganese exposure: Pilot study with clinical, environmental and experimental evidence |
title_sort | parkinsonism and chronic manganese exposure: pilot study with clinical, environmental and experimental evidence |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298767/ https://www.ncbi.nlm.nih.gov/pubmed/34316640 http://dx.doi.org/10.1016/j.prdoa.2020.100057 |
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