Cargando…

The Association between Behavioral Risk Factors and Nontuberculous Mycobacterial Pulmonary Disease

PURPOSE: We aimed to determine the relationship between environmental exposure and nontuberculous mycobacterial pulmonary disease (NTM-PD) in Korea. MATERIALS AND METHODS: A group of 150 patients with NTM-PD and a control group of 217 patients with other respiratory diseases were prospectively enrol...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Youngmok, Kwak, Se Hyun, Yong, Seung Hyun, Lee, Su Hwan, Leem, Ah Young, Kim, Song Yee, Lee, Sang Hoon, Chung, Kyungsoo, Kim, Eun Young, Jung, Ji Ye, Park, Moo Suk, Kim, Young Sam, Chang, Joon, Kang, Young Ae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298869/
https://www.ncbi.nlm.nih.gov/pubmed/34296547
http://dx.doi.org/10.3349/ymj.2021.62.8.702
Descripción
Sumario:PURPOSE: We aimed to determine the relationship between environmental exposure and nontuberculous mycobacterial pulmonary disease (NTM-PD) in Korea. MATERIALS AND METHODS: A group of 150 patients with NTM-PD and a control group of 217 patients with other respiratory diseases were prospectively enrolled between June 2018 and December 2020 in Seoul, Korea. They were surveyed with a standardized questionnaire, and their medical records were reviewed. Odds ratio (OR) and 95% confidence intervals (CI) were calculated with multivariate logistic regression analysis. RESULTS: The mean ages of the NTM-PD and control groups were similar (63.8±9.2 years vs. 63.5±10.0 years; p=0.737), and most patients were female (76.0% vs. 68.7%; p=0.157) and nonsmokers (82.0% vs. 72.8%; p=0.021). Mycobacterium avium (49.3%) was the most commonly identified strain among NTM-PD patients, followed by M. intracellulare (32.0%) and M. abscessus subspecies massiliense (12.7%). There were no differences in housing type or frequency of soil- or pet-related exposure between the case and the control groups. However, in subgroup analysis excluding patients with M. intracellulare infection, more case patients frequently visited public baths ≥1 time/week (35.3% vs. 19.4%, p=0.003); this remained significant after multivariate analysis (OR, 2.84; 95% CI, 1.58–5.17). CONCLUSION: Frequent exposure to water at public baths might affect the odds of contracting NTM-PD, excluding individuals infected with M. intracellulare strains.