Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report

The widely used Xpert MTB/RIF assay, limited by its suboptimal sensitivity, does not perform well as a rule‐out test for tuberculous meningitis. Alternative CSF‐based biomarkers can help determine the microbial etiology of clinical meningitis when standard diagnostic modalities fail.

Detalles Bibliográficos
Autores principales: Poudel, Deechit, Poudel, Diptee, Poudel, Dhiraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299261/
https://www.ncbi.nlm.nih.gov/pubmed/34322264
http://dx.doi.org/10.1002/ccr3.4526
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author Poudel, Deechit
Poudel, Diptee
Poudel, Dhiraj
author_facet Poudel, Deechit
Poudel, Diptee
Poudel, Dhiraj
author_sort Poudel, Deechit
collection PubMed
description The widely used Xpert MTB/RIF assay, limited by its suboptimal sensitivity, does not perform well as a rule‐out test for tuberculous meningitis. Alternative CSF‐based biomarkers can help determine the microbial etiology of clinical meningitis when standard diagnostic modalities fail.
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spelling pubmed-82992612021-07-27 Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report Poudel, Deechit Poudel, Diptee Poudel, Dhiraj Clin Case Rep Case Report The widely used Xpert MTB/RIF assay, limited by its suboptimal sensitivity, does not perform well as a rule‐out test for tuberculous meningitis. Alternative CSF‐based biomarkers can help determine the microbial etiology of clinical meningitis when standard diagnostic modalities fail. John Wiley and Sons Inc. 2021-07-23 /pmc/articles/PMC8299261/ /pubmed/34322264 http://dx.doi.org/10.1002/ccr3.4526 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Poudel, Deechit
Poudel, Diptee
Poudel, Dhiraj
Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report
title Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report
title_full Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report
title_fullStr Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report
title_full_unstemmed Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report
title_short Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report
title_sort use of alternative cerebrospinal fluid‐based biomarkers to help diagnose xpert‐negative tuberculous meningitis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299261/
https://www.ncbi.nlm.nih.gov/pubmed/34322264
http://dx.doi.org/10.1002/ccr3.4526
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